[人类母乳喂养的表观遗传效应]
[Epigenetic effects of human breastfeeding].
作者信息
Ma Jing-Ran, Wang Dan-Hua
机构信息
Department of Pediatrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.
出版信息
Zhongguo Dang Dai Er Ke Za Zhi. 2016 Oct;18(10):926-930. doi: 10.7499/j.issn.1008-8830.2016.10.002.
Breastfeeding is well-known for its benefits of preventing communicable and non-communicable diseases. Human breastmilk consists not only of nutrients, but also of bioactive substances. What's more, the epigenetic effects of human breast milk may also play an important role. Alterations in the epigenetic regulation of genes may lead to profound changes in phenotype. Clarifying the role of human breast milk on genetic expression can potentially benefit the infant's health and his later life. This review article makes a brief summary of the epigenetic mechanism of breast milk, and its epigenetic effects on neonatal necrotizing enterocolitis, infectious diseases, metabolism syndrome, cognitive function and anaphylactic diseases.
母乳喂养因其预防传染病和非传染病的益处而广为人知。人乳不仅含有营养物质，还含有生物活性物质。此外，人乳的表观遗传效应可能也起着重要作用。基因表观遗传调控的改变可能导致表型的深刻变化。阐明人乳对基因表达的作用可能有益于婴儿的健康及其日后的生活。这篇综述文章简要总结了母乳的表观遗传机制及其对新生儿坏死性小肠结肠炎、传染病、代谢综合征、认知功能和过敏性疾病的表观遗传效应。
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