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[营养表观遗传学与人乳的表观遗传效应]

[Nutritional epigenetics and epigenetic effects of human breast milk].

作者信息

Lukoyanova O L, Borovik T E

出版信息

Vopr Pitan. 2015;84(5):4-15.

Abstract

The article provides an overview of the current literature on nutritional epigenetics. There are currently actively studied hypothesis that nutrition especially in early life or in critical periods of the development, may have a role in modulating gene expression, and, therefore, have later effects on health in adults. Nutritional epigenetics concerns knowledge about the possible effects of nutrients on gene expression. Human breast milk is well-known for its ability in preventing necrotizing enterocolitis, infectious diseases, and also non-communicable diseases, such as obesity and related disorders. This paper discusses about presumed epigenetic effects of human breast milk and some its components. While evidence suggests that a direct relationship may exist of some components of human breast milk with epigenetic changes, the mechanisms involved are stillunclear.

摘要

本文概述了当前关于营养表观遗传学的文献。目前有一些正在积极研究的假说,即营养,尤其是在生命早期或发育的关键时期,可能在调节基因表达中发挥作用,因此对成年人的健康有后期影响。营养表观遗传学涉及营养素对基因表达可能产生的影响的相关知识。人乳以其预防坏死性小肠结肠炎、传染病以及肥胖症和相关疾病等非传染性疾病的能力而闻名。本文讨论了人乳及其某些成分可能存在的表观遗传效应。虽然有证据表明人乳的某些成分可能与表观遗传变化存在直接关系,但其中涉及的机制仍不清楚。

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