精氨酸补充剂对军事人员的安全性和性能益处：一项系统综述。
Safety and performance benefits of arginine supplements for military personnel: a systematic review.
作者信息
Brooks James R, Oketch-Rabah Hellen, Low Dog Tieraona, Gorecki Dennis K J, Barrett Marilyn L, Cantilena Louis, Chung Mei, Costello Rebecca B, Dwyer Johanna, Hardy Mary L, Jordan Scott A, Maughan Ronald J, Marles Robin J, Osterberg Robert E, Rodda Bruce E, Wolfe Robert R, Zuniga Jorge M, Valerio Luis G, Jones Donnamaria, Deuster Patricia, Giancaspro Gabriel I, Sarma Nandakumara D
机构信息
J.R. Brooks, M.L. Barrett, L. Cantilena, R.B. Costello, J. Dwyer, M.L. Hardy, S.A. Jordan, R.J. Maughan, R.J. Marles, R.E. Osterberg, B.E. Rodda, R.R. Wolfe, and J.M. Zuniga are with the US Pharmacopeial Convention Arginine Review Expert Panel. T. Low Dog, D.K.J. Gorecki, L. Cantilena, M. Chung, R.B. Costello, and S.A. Jordan are with the US Pharmacopeial Convention Evidence-Based Reviews Expert Panel. L.G. Valerio Jr is with the US Food and Drug Administration liaison to the US Pharmacopeial Convention Dietary Supplements Expert Committee and with Verto Solutions LLC, Washington, DC, USA. G.I. Giancaspro, H. Oketch-Rabah, and N.D. Sarma are with the US Pharmacopeial Convention, Rockville, Maryland, USA. D. Jones and P. Deuster are with the Uniformed Services University of Health Sciences, Bethesda, Maryland, USA.
出版信息
Nutr Rev. 2016 Nov;74(11):708-721. doi: 10.1093/nutrit/nuw040.
CONTEXT
Dietary supplements are widely used by military personnel and civilians for promotion of health.
OBJECTIVE
The objective of this evidence-based review was to examine whether supplementation with l-arginine, in combination with caffeine and/or creatine, is safe and whether it enhances athletic performance or improves recovery from exhaustion for military personnel.
DATA SOURCES
Information from clinical trials and adverse event reports were collected from 17 databases and 5 adverse event report portals.
STUDY SELECTION
Studies and reports were included if they evaluated the safety and the putative outcomes of enhanced performance or improved recovery from exhaustion associated with the intake of arginine alone or in combination with caffeine and/or creatine in healthy adults aged 19 to 50 years.
DATA EXTRACTION
Information related to population, intervention, comparator, and outcomes was abstracted. Of the 2687 articles screened, 62 articles meeting the inclusion criteria were analyzed. Strength of evidence was assessed in terms of risk of bias, consistency, directness, and precision.
RESULTS
Most studies had few participants and suggested risk of bias that could negatively affect the results. l-Arginine supplementation provided little enhancement of athletic performance or improvements in recovery. Short-term supplementation with arginine may result in adverse gastrointestinal and cardiovascular effects. No information about the effects of arginine on the performance of military personnel was available.
CONCLUSIONS
The available information does not support the use of l-arginine, either alone or in combination with caffeine, creatine, or both, to enhance athletic performance or improve recovery from exhaustion. Given the information gaps, an evidence-based review to assess the safety or effectiveness of multi-ingredient dietary supplements was not feasible, and therefore the development of a computational model-based approach to predict the safety of multi-ingredient dietary supplements is recommended.
背景
膳食补充剂被军事人员和平民广泛用于促进健康。
目的
本循证综述的目的是研究补充L-精氨酸并结合咖啡因和/或肌酸是否安全，以及它是否能提高军事人员的运动表现或改善疲劳恢复情况。
数据来源
从17个数据库和5个不良事件报告平台收集了来自临床试验和不良事件报告的信息。
研究选择
纳入评估单独摄入精氨酸或与咖啡因和/或肌酸联合摄入对19至50岁健康成年人增强运动表现或改善疲劳恢复的安全性及假定结果的研究和报告。
数据提取
提取与人群、干预措施、对照和结果相关的信息。在筛选的2687篇文章中，分析了62篇符合纳入标准的文章。根据偏倚风险、一致性、直接性和精确性评估证据强度。
结果
大多数研究参与者较少，存在可能对结果产生负面影响的偏倚风险。补充L-精氨酸对运动表现的提升或恢复改善作用不大。短期补充精氨酸可能会导致不良的胃肠道和心血管影响。没有关于精氨酸对军事人员表现影响的信息。
结论
现有信息不支持单独使用L-精氨酸或与咖啡因、肌酸或两者联合使用来提高运动表现或改善疲劳恢复。鉴于信息缺口，基于证据评估多成分膳食补充剂安全性或有效性的综述不可行，因此建议开发一种基于计算模型的方法来预测多成分膳食补充剂的安全性。
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