Dutta Subarna, Bhattacharyya Maitree, Sengupta Kaushik
Biophysics & Structural Genomics Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700064, West Bengal, India.
Department of Biochemistry, University of Calcutta, 35, Ballygunge Circular Road, Kolkata 700019, West Bengal, India.
Cells. 2016 Oct 14;5(4):37. doi: 10.3390/cells5040037.
Lamins are mechanosensitive and elastic components of the nuclear lamina that respond to external mechanical cues by altering gene regulation in a feedback mechanism. Numerous mutations in A-type lamins cause a plethora of diverse diseases collectively termed as laminopathies, the majority of which are characterized by irregularly shaped, fragile, and plastic nuclei. These nuclei are challenged to normal mechanotransduction and lead to disease phenotypes. Here, we review our current understanding of the nucleocytoskeleton coupling in mechanotransduction mediated by lamins. We also present an up-to-date understanding of the methods used to determine laminar elasticity both at the bulk and single molecule level.
核纤层蛋白是核纤层的机械敏感和弹性成分，通过反馈机制改变基因调控来响应外部机械信号。A型核纤层蛋白的众多突变会导致大量不同的疾病，统称为核纤层蛋白病，其中大多数的特征是细胞核形状不规则、脆弱且具有可塑性。这些细胞核在正常机械转导方面受到挑战，并导致疾病表型。在此，我们综述了目前对核纤层蛋白介导的机械转导中核细胞骨架耦合的理解。我们还介绍了在整体和单分子水平上用于确定核纤层弹性的方法的最新认识。
