Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Melbourne, VIC, Australia,
Department of Medicine, Western Health, Melbourne Medical School, University of Melbourne, St Albans, Melbourne, VIC, Australia,
Clin Interv Aging. 2019 Feb 19;14:389-398. doi: 10.2147/CIA.S168687. eCollection 2019.
The term "frailty" is used to describe a subset of older adults who appear weaker and more vulnerable than their age-matched counterparts, despite having similar comorbidities, demography, sex, and age. The diagnosis of frailty is usually clinical and based on specific criteria, which are sometimes inconsistent. Therefore, there is an increasing need to identify and validate robust biomarkers for this condition. In this review, we summarize current evidence on the validity and practicality of the most commonly used biomarkers for frailty, while also comparing them with new upcoming strategies to identify this condition.
“虚弱”一词用于描述一组老年人，他们看起来比年龄相仿的人更虚弱、更容易受到伤害，尽管他们有相似的合并症、人口统计学、性别和年龄。虚弱的诊断通常是临床的，并基于特定的标准，这些标准有时并不一致。因此，人们越来越需要识别和验证这种情况的强大生物标志物。在这篇综述中，我们总结了目前关于最常用的虚弱生物标志物的有效性和实用性的证据，同时也比较了新出现的识别这种情况的策略。
