Xu Chen, Kan Hai-Dong, Fan Yan-Ni, Chen Ren-Jie, Liu Jiang-Hong, Li Ya-Fei, Zhang Yao, Ji Ai-Ling, Cai Tong-Jian
a Department of Epidemiology, College of Preventive Medicine , Third Military Medical University , Chongqing , China.
b Department of Environmental Health, School of Public Health , Fudan University , Shanghai , China.
J Toxicol Environ Health A. 2016;79(24):1183-1189. doi: 10.1080/15287394.2016.1227006. Epub 2016 Oct 18.
The correlation between enteritis, a common digestive disease, and exposure to ambient air pollutants has not been examined in a comprehensive manner. The aim of this study was to determine whether an association between short-term air pollution exposure and outpatient visits for enteritis in Xi'an, China, occurred using a time-series investigation. Daily baseline data from January 1, 2013, to December 31, 2015, were obtained. The overdispersed Poisson generalized additive model was used to analyze the association between air pollutant levels and frequency of enteritis. A total of 12,815 outpatient hospital visits for enteritis were identified. A 10-µg/m increase in average concentrations of particulate matter (PM), PM, nitrogen dioxide (NO), and sulfur dioxide (SO), and a 0.1-mg/m rise of carbon monoxide (CO) were associated with a significantly elevated number of outpatient visits for enteritis on concurrent days, while ozone (O) did not markedly affect the frequency of enteritis clinical visits. There were no significant positive effects between two-pollutant and single-pollutant models. Lag models showed that the most prominent responses occurred on concurrent days. Confounding factors of gender and age played a significant role in the observations. Taken together, data indicate that air pollution may result in enhanced occurrence of enteritis attack.
常见消化系统疾病肠炎与暴露于环境空气污染物之间的相关性尚未得到全面研究。本研究的目的是通过时间序列调查来确定中国西安短期空气污染暴露与肠炎门诊就诊之间是否存在关联。获取了2013年1月1日至2015年12月31日的每日基线数据。采用过度分散的泊松广义相加模型分析空气污染物水平与肠炎发生频率之间的关联。共确定了12815例肠炎门诊就诊病例。颗粒物（PM）、PM、二氧化氮（NO）和二氧化硫（SO）的平均浓度每增加10μg/m，一氧化碳（CO）浓度每升高0.1mg/m，与同期肠炎门诊就诊病例数显著增加相关，而臭氧（O）对肠炎临床就诊频率没有明显影响。双污染物模型和单污染物模型之间没有显著的正向影响。滞后模型显示，最显著的反应发生在同期。性别和年龄等混杂因素在观察中起了重要作用。综合来看，数据表明空气污染可能导致肠炎发作的发生率增加。
