用于新型糖脂质体开发的三甘露糖基化古菌二醚脂质的合成。
Synthesis of a trimannosylated-equipped archaeal diether lipid for the development of novel glycoliposomes.
作者信息
Barbeau Julie, Lemiègre Loïc, Quelen Allan, Malard Virginie, Gao Haifei, Gonçalves Cristine, Berchel Mathieu, Jaffrès Paul-Alain, Pichon Chantal, Midoux Patrick, Benvegnu Thierry
机构信息
Ecole Nationale Supérieure de Chimie de Rennes, CNRS UMR 6226, 11 Allée de Beaulieu, CS 50837, 35708 Rennes Cedex 7, France; Université de Bretagne Loire, France.
Centre de Biophysique Moléculaire, CNRS UPR 4301, Université d'Orléans, rue Charles Sadron, CS 80054, 45071 Orléans, France.
出版信息
Carbohydr Res. 2016 Nov 29;435:142-148. doi: 10.1016/j.carres.2016.10.003. Epub 2016 Oct 11.
An archaeal diether lipid possessing a tri-antenna of α-D-mannopyranoside linked via an oligoethylene spacer to a (2S)-2-(phytanyloxy)-3-(hexadecyloxy)propanoic acid backbone (TriMan-Diether) was designed and synthesized. This new mannosylated lipid inserted in liposomes would show both DC-targeting and adjuvant properties thanks to the TriMan structure and the diether tail part, respectively.
设计并合成了一种古细菌二醚脂质，其具有通过低聚亚乙基间隔基连接到(2S)-2-(植烷氧基)-3-(十六烷氧基)丙酸主链上的α-D-甘露吡喃oside三天线（TriMan-二醚）。由于TriMan结构和二醚尾部，这种插入脂质体中的新型甘露糖基化脂质将分别显示出靶向树突状细胞和佐剂特性。
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