Rheumatology Andrew Finch, Rheumatologist Paul Kubler
Royal Brisbane and Women's Hospital, Brisbane.
Aust Prescr. 2016 Aug;39(4):119-122. doi: 10.18773/austprescr.2016.047. Epub 2016 Aug 1.
Gout is a common inflammatory arthritis that is increasing in prevalence. It is caused by the deposition of urate crystals. Non-steroidal anti-inflammatory drugs, colchicine and corticosteroids are options for the management of acute gout. They are equally efficacious and comorbidities guide the best choice. Allopurinol is an effective treatment for reducing concentrations of uric acid. Renal function guides the starting dose of allopurinol and the baseline serum uric acid concentration guides the maintenance dose. Febuxostat is another xanthine oxidase inhibitor. It is clinically equivalent to allopurinol. Uricosuric drugs, such as probenecid, increase uric acid excretion. New drugs in this class will soon become available and are likely to have a role in the treatment of patients who do not respond to other drugs.
痛风是一种常见的炎症性关节炎，其患病率正在上升。它由尿酸盐结晶沉积所致。非甾体抗炎药、秋水仙碱和糖皮质激素是治疗急性痛风的选择。它们疗效相当，合并症指导最佳选择。别嘌醇是降低尿酸浓度的有效治疗药物。肾功能指导别嘌醇的起始剂量，基线血清尿酸浓度指导维持剂量。非布司他是另一种黄嘌呤氧化酶抑制剂。它在临床上与别嘌醇等效。促尿酸排泄药，如丙磺舒，可增加尿酸排泄。此类新药即将上市，可能在治疗对其他药物无反应的患者中发挥作用。
