添加乳铁蛋白对配方奶粉中铁生物利用率的影响。
Iron bioavailability from supplemented formula milk: effect of lactoferrin addition.
机构信息
Department of Physical and Analytical Chemistry, Faculty of Chemistry, University of Oviedo, Avda Julián Clavería, 33006, Oviedo, Asturias, Spain.
"Fundación de Investigación Oftalmológica", Instituto Oftalmológico Fernández-Vega, Avda Doctores Fernández Vega, 33012, Oviedo, Asturias, Spain.
出版信息
Eur J Nutr. 2017 Dec;56(8):2611-2620. doi: 10.1007/s00394-016-1325-7. Epub 2016 Oct 18.
PURPOSE
In this work, the absorption and/or bioavailability of iron from two chemical species, Fe-Lf (apo-lactoferrin) complex and FeSO at low and high dose, and in Lf excess were investigated in lactating wistar rats.
METHODS
The methodology used is based on the use of stable isotopes in combination with the approach "isotope pattern deconvolution" and ICP-MS for detection. This approach provides quantitative information about exogenous (Fe) and endogenous iron (Fe) distribution in fluids and tissues in the iron-supplemented rat groups.
RESULTS
The observed results with supplemented rats were compared with those found in rats receiving maternal feeding. Interestingly, differences were found between groups in iron for transport and storage compartments, but not in the functional one, depending upon the dose of iron administered and the chemical species.
CONCLUSION
Considering the results obtained, supplementation with iron salts in excess of Lf appears to be the best way of iron supplementation of formula milk.
目的
本研究旨在探究低剂量和高剂量下两种铁化学物质（Fe-Lf[脱铁乳铁蛋白]复合物和 FeSO）以及Lf 过量时的铁吸收和/或生物利用度。
方法
本研究采用基于稳定同位素结合“同位素模式反卷积”和 ICP-MS 检测的方法。该方法为补充铁的大鼠组中外源（Fe）和内源性铁（Fe）在液体和组织中的分布提供了定量信息。
结果
与接受母体喂养的大鼠相比，补充铁的大鼠的观察结果存在差异。有趣的是，铁的转运和储存部位存在组间差异，但功能部位无差异，这取决于给予的铁剂量和化学物质。
结论
考虑到所获得的结果，铁盐的补充超过 Lf 似乎是配方奶粉中铁补充的最佳方式。
Zotero 插件