Su L, Faluyi Y O, Hong Y T, Fryer T D, Mak E, Gabel S, Hayes L, Soteriades S, Williams G B, Arnold R, Passamonti L, Rodríguez P Vázquez, Surendranathan A, Bevan-Jones R W, Coles J, Aigbirhio F, Rowe J B, O'Brien J T
Li Su, PhD, Yetunde O. Faluyi, MBChB, Department of Psychiatry, University of Cambridge, UK; Young T. Hong, PhD, Tim D. Fryer, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Elijah Mak, BA, Department of Psychiatry, University of Cambridge, UK; Silvy Gabel, MSc, Department of Psychiatry, University of Cambridge, UK and Faculty of Psychology and Neuroscience, Maastricht University, the Netherlands; Lawrence Hayes, MBBS, Soteris Soteriades, BA, Department of Psychiatry, University of Cambridge, UK; Guy B. Williams, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Robert Arnold, BSc, Department of Psychiatry, University of Cambridge, UK; Luca Passamonti, MD, Patricia Vázquez Rodríguez, MSc, Department of Clinical Neurosciences, University of Cambridge, UK, Ajenthan Surendranathan, MRCP, Richard W. Bevan-Jones, MBBChir, Department of Psychiatry, University of Cambridge, UK; Jonathan Coles, PhD, Division of Anaesthesia, Department of Medicine, University of Cambridge, UK; Franklin Aigbirhio, DPhil, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; James B. Rowe, PhD, Department of Clinical Neurosciences, University of Cambridge and Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, UK; John T. O'Brien, DM, Department of Psychiatry, University of Cambridge, UK
Li Su, PhD, Yetunde O. Faluyi, MBChB, Department of Psychiatry, University of Cambridge, UK; Young T. Hong, PhD, Tim D. Fryer, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Elijah Mak, BA, Department of Psychiatry, University of Cambridge, UK; Silvy Gabel, MSc, Department of Psychiatry, University of Cambridge, UK and Faculty of Psychology and Neuroscience, Maastricht University, the Netherlands; Lawrence Hayes, MBBS, Soteris Soteriades, BA, Department of Psychiatry, University of Cambridge, UK; Guy B. Williams, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Robert Arnold, BSc, Department of Psychiatry, University of Cambridge, UK; Luca Passamonti, MD, Patricia Vázquez Rodríguez, MSc, Department of Clinical Neurosciences, University of Cambridge, UK, Ajenthan Surendranathan, MRCP, Richard W. Bevan-Jones, MBBChir, Department of Psychiatry, University of Cambridge, UK; Jonathan Coles, PhD, Division of Anaesthesia, Department of Medicine, University of Cambridge, UK; Franklin Aigbirhio, DPhil, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; James B. Rowe, PhD, Department of Clinical Neurosciences, University of Cambridge and Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, UK; John T. O'Brien, DM, Department of Psychiatry, University of Cambridge, UK.
Br J Psychiatry. 2016 Dec;209(6):525-526. doi: 10.1192/bjp.bp.116.190165. Epub 2016 Oct 6.
We studied neuroinflammation in individuals with late-life depression, as a risk factor for dementia, using [C]PK11195 positron emission tomography (PET). Five older participants with major depression and 13 controls underwent PET and multimodal 3T magnetic resonance imaging (MRI), with blood taken to measure C-reactive protein (CRP). We found significantly higher CRP levels in those with late-life depression and raised [C]PK11195 binding compared with controls in brain regions associated with depression, including subgenual anterior cingulate cortex, and significant hippocampal subfield atrophy in cornu ammonis 1 and subiculum. Our findings suggest neuroinflammation requires further investigation in late-life depression, both as a possible aetiological factor and a potential therapeutic target.
我们使用[C]PK11195正电子发射断层扫描（PET）研究了老年期抑郁症患者的神经炎症，将其作为痴呆症的一个风险因素。五名患有重度抑郁症的老年参与者和13名对照者接受了PET和多模态3T磁共振成像（MRI）检查，并采集血液以测量C反应蛋白（CRP）。我们发现，与对照组相比，老年期抑郁症患者的CRP水平显著升高，且在与抑郁症相关的脑区，包括膝下前扣带回皮质，[C]PK11195结合增加，并且海马角1和下托存在显著的海马亚区萎缩。我们的研究结果表明，神经炎症在老年期抑郁症中需要进一步研究，既是可能的病因因素，也是潜在的治疗靶点。
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