Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht and Utrecht University, Utrecht, The Netherlands.
Department of Geriatrics, University Medical Center Utrecht and Utrecht University, Utrecht, The Netherlands.
Hum Brain Mapp. 2023 Apr 1;44(5):1964-1984. doi: 10.1002/hbm.26185. Epub 2022 Dec 30.
Specific subfields within the hippocampus have shown vulnerability to chronic stress, highlighting the importance of looking regionally within the hippocampus to understand the role of psychosocial factors in the development of neurodegenerative diseases. A systematic review on psychosocial factors and hippocampal subfield volumes was performed and showed inconsistent results, highlighting the need for future studies to explore this relationship. The current study aimed to explore the association of psychosocial factors with hippocampal (subfield) volumes, using high-field 7T MRI. Data were from the Memory Depression and Aging (Medea)-7T study, which included 333 participants without dementia. Hippocampal subfields were automatically segmented from T2-weighted images using ASHS software. Generalized linear models accounting for correlated outcomes were used to assess the association between subfields (i.e., entorhinal cortex, subiculum, Cornu Ammonis [CA]1, CA2, CA3, dentate gyrus, and tail) and each psychosocial factor (i.e., depressive symptoms, anxiety symptoms, childhood maltreatment, recent stressful life events, and social support), adjusted for age, sex, and intracranial volume. Neither depression nor anxiety was associated with specific hippocampal (subfield) volumes. A trend for lower total hippocampal volume was found in those reporting childhood maltreatment, and a trend for higher total hippocampal volume was found in those who experienced a recent stressful life event. Among subfields, low social support was associated with lower volume in the CA3 (B = -0.43, 95% CI: -0.72; -0.15). This study suggests possible differential effects among hippocampal (subfield) volumes and psychosocial factors.
特定的海马亚区对慢性应激表现出易损性，这突出表明，需要在海马亚区内进行区域性研究，以了解心理社会因素在神经退行性疾病发展中的作用。对心理社会因素与海马亚区体积的关系进行了系统综述，结果显示不一致，突出表明未来研究需要探索这种关系。本研究旨在使用高场 7T MRI 探讨心理社会因素与海马（亚区）体积的关系。数据来自无痴呆的 333 名参与者的记忆、抑郁和衰老（Medea）-7T 研究。使用 ASHS 软件从 T2 加权图像自动分割出海马亚区。使用考虑相关结果的广义线性模型评估亚区（即内嗅皮层、下托、CA1、CA2、CA3、齿状回和尾部）与每个心理社会因素（即抑郁症状、焦虑症状、儿童期虐待、近期生活压力事件和社会支持）之间的关联，调整了年龄、性别和颅内体积。抑郁和焦虑均与特定的海马（亚区）体积无关。在报告儿童期虐待的人群中，总海马体积呈下降趋势，而在经历近期生活压力事件的人群中，总海马体积呈上升趋势。在亚区中，低社会支持与 CA3 体积减少相关（B=-0.43，95%CI：-0.72；-0.15）。这项研究表明，海马（亚区）体积和心理社会因素之间可能存在差异效应。
