State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, College of Chemistry, Chemical Engineering and Materials Science, Soochow University , Suzhou 215123, China.
School of Biology and Basic Medical Science, Soochow University , Suzhou 215123, China.
ACS Appl Mater Interfaces. 2016 Nov 9;8(44):29906-29914. doi: 10.1021/acsami.6b08624. Epub 2016 Oct 26.
In this work, we reported the generation of a novel supramolecular hydrogelator from a peptide derivative which consisted of a structural motif (e.g., Fc-FF) for supramolecular self-assembly and a functional moiety (e.g., RGD) for integrin binding. Following self-assembly in water at neutral pH, this molecule first tended to form metastable spherical aggregates, which subsequently underwent a morphological transformation to form high-aspect-ratio nanostructures over 2 h when aged at room temperature. More importantly, because of the presence of nanoscale RGD clusters on the surface of nanostructures, the self-assembled nanomaterials (e.g., nanoparticles and nanofibers) can be potentially used as a biomimetic matrix for cell culture and as a vector for cell-targeting drug delivery via multivalent RGD-integrin interactions.
在这项工作中，我们报道了一种新型超分子水凝胶因子的产生，该水凝胶因子由一个结构基序（例如 Fc-FF）和一个功能部分（例如 RGD）组成，用于超分子自组装和整合素结合。在中性 pH 的水中自组装后，该分子首先倾向于形成亚稳的球形聚集体，随后在室温下老化 2 小时时，这些聚集体经历形态转变，形成具有高纵横比的纳米结构。更重要的是，由于纳米结构表面存在纳米级 RGD 簇，自组装纳米材料（例如纳米颗粒和纳米纤维）可潜在用作细胞培养的仿生基质，并可通过多价 RGD-整合素相互作用作为细胞靶向药物传递的载体。
