Orazov M R, Nosenko E N, Radzinsky V E, Khamoshina M B, Lebedeva M G, Sounov M A
a Federal State Autonomous educational institution "Peoples' Friendship University of Russia" , Moscow , Russia and.
b "Odessa National Medical University" Ministry of Health of the Ukraine , Odessa , Ukraine.
Gynecol Endocrinol. 2016 Oct;32(sup2):7-10. doi: 10.1080/09513590.2016.1232902.
The study of peculiarities of expression of vascular endothelial growth factor (VEGF) in the tissues of the endometrium and myometrium in patients with adenomyosis, associated with chronic pelvic pain syndrome.
Uterus macro-preparations obtained after hysterectomy in 60 patients with pelvic pain on a background of diffuse adenomyosis II-III degree were used for morphological examination, and macro-preparations received from 30 women with adenomyosis without pain syndrome. The diagnosis of adenomyosis was confirmed by sonography and magnetic resonance imaging. The expression of VEGF in tissues of the endometrium and myometrium was determined using the immune-histochemical method. The significance of differences of the compared parameters was determined using the criterion of Wilcoxon and Mann-Whitney. The differences were considered statistically significant when p < 0.05.
It was found that a higher expression of VEGF is characteristic for patients with pelvic pain associated with adenomyosis, compared to women with adenomyosis and abnormal uterine bleeding, both in epithelial cells of ectopic endometrium (14.7 ± 1.6% against 10.7 ± 1.6%, p < 0.01), and in smooth myocytes of the myometrium (12.6 ± 1.4% against 9.6 ± 1.2%, p < 0.01) and in the stromal cells of the myometrium (10.1 ± 1.9% versus 7.4 ± 1.8%, p < 0.01).
An increased expression of VEGF in the tissues of the uterus is one of the most important pathogenetic mechanisms of algogenesis with adenomyosis, associated syndrome of chronic pelvic pain, compared to the silent form of the disease.
研究子宫腺肌病患者子宫内膜和肌层组织中血管内皮生长因子（VEGF）表达的特点，该疾病与慢性盆腔疼痛综合征相关。
对60例因弥漫性Ⅱ - Ⅲ度子宫腺肌病伴盆腔疼痛行子宫切除术后获得的子宫大体标本进行形态学检查，同时对30例无疼痛综合征的子宫腺肌病女性的大体标本进行研究。子宫腺肌病的诊断通过超声和磁共振成像得以证实。采用免疫组织化学方法测定子宫内膜和肌层组织中VEGF的表达。使用Wilcoxon和Mann - Whitney标准确定比较参数差异的显著性。当p < 0.05时，差异被认为具有统计学意义。
发现与患有子宫腺肌病和异常子宫出血的女性相比，伴有盆腔疼痛的子宫腺肌病患者在异位子宫内膜上皮细胞（14.7 ± 1.6% 对比 10.7 ± 1.6%，p < 0.01）、肌层平滑肌细胞（12.6 ± 1.4% 对比 9.6 ± 1.2%，p < 0.01）以及肌层基质细胞（10.1 ± 1.9% 对比 7.4 ± 1.8%，p < 0.01）中VEGF表达更高。
与疾病的无症状形式相比，子宫组织中VEGF表达增加是子宫腺肌病伴慢性盆腔疼痛相关综合征疼痛发生的最重要发病机制之一。
