Li Qingsheng, Egilmez Nejat K
a Department of Microbiology and Immunology , School of Medicine, University of Louisville , Louisville , KY , USA.
Immunol Invest. 2016 Nov;45(8):729-745. doi: 10.1080/08820139.2016.1220390. Epub 2016 Oct 19.
The critical contribution of CD4+CD25+Foxp3+ T-regulatory cells (Treg) to immune suppression in the tumor microenvironment is well-established. Whereas the mechanisms that drive the generation and accumulation of Treg in tumors have been an active area of study, the information on their origin and population dynamics remains limited. In this review, we discuss the ontogeny of tumor-associated Treg in light of the recently identified lineage markers.
CD4+CD25+Foxp3+调节性T细胞（Treg）对肿瘤微环境中免疫抑制的关键作用已得到充分证实。尽管驱动Treg在肿瘤中产生和积累的机制一直是一个活跃的研究领域，但其起源和群体动态的信息仍然有限。在这篇综述中，我们根据最近鉴定出的谱系标志物来讨论肿瘤相关Treg的个体发生。
