Department of Pediatrics, Hematology and Oncology, Medical University of Gdansk, Poland.
Clinical Immunology and Transplantology Unit at the Department of Immunology, Medical University of Gdansk, Poland.
J Immunol Res. 2019 Mar 3;2019:2816498. doi: 10.1155/2019/2816498. eCollection 2019.
Regulatory T-cells (Tregs) are a very important subtype of lymphocytes when it comes to self-control in the human immunological system. Tregs are decisive not only in the protection against destruction of own tissues by autoimmune immunocompetent cells but also in the immunological answer to developing cancers. On the other hand, Tregs could be responsible for the progression of acute and chronic leukemias. In our study, we review publications available in the PUMED database concerning acute leukemia, with a particular emphasis on child's leukemias. The percentage of regulatory T-lymphocytes in peripheral blood and bone marrow was elevated compared to those in healthy individuals and correlated with progressive disease. Regulatory T-cells taken from children diagnosed with leukemia showed a higher suppressive capability, which was confirmed by detecting elevated levels of secreted IL-10 and TGF-beta. The possibility of pharmacological intervention in the self-control of the immunological system is now under extensive investigation in many human cancers. Presumably, Treg cells could be a vital part of targeted therapies. Routine Treg determination could be used to assess the severity of disease and prognosis in children with acute lymphoblastic leukemia. This proposition results from the fact that in some studies, higher percentage of Treg cells in peripheral blood was demonstrated. However, observations confirming these facts are scarce; thus, extrapolating them to the population of children with hematological malignancies needs to be verified in additional studies.
调节性 T 细胞（Tregs）在人类免疫系统的自我控制中是非常重要的淋巴细胞亚群。Tregs 不仅在防止自身免疫细胞破坏自身组织方面起决定性作用，而且在癌症发展的免疫反应中也起决定性作用。另一方面，Tregs 可能是急性和慢性白血病进展的原因。在我们的研究中，我们回顾了 PUMED 数据库中关于急性白血病的出版物，特别强调了儿童白血病。与健康个体相比，外周血和骨髓中的调节性 T 淋巴细胞百分比升高，并且与进行性疾病相关。从诊断为白血病的儿童中分离出的调节性 T 细胞显示出更高的抑制能力，这通过检测到升高的分泌 IL-10 和 TGF-β 水平得到证实。目前，许多人类癌症正在广泛研究免疫自我控制的药物干预可能性。推测 Treg 细胞可能是靶向治疗的重要组成部分。常规 Treg 测定可用于评估急性淋巴细胞白血病儿童的疾病严重程度和预后。这一观点源于一些研究中，在外周血中发现 Treg 细胞的百分比较高。然而，证实这些事实的观察结果很少；因此，需要在进一步的研究中验证将其推断为血液恶性肿瘤儿童的人群。
