Brito-Filho Sebastião Barreto de, Moura Egberto Gaspar de, Santos Orlando José Dos, Sauaia-Filho Euler Nicolau, Amorim Elias, Santana Ewaldo Eder Carvalho, Barros-Filho Allan Kardec Dualibe, Santos Rennan Abud Pinheiro
Academic League in Experimental Surgery Laboratory, School of Medicine, Federal University of Maranhão and State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Arq Bras Cir Dig. 2016 Jul-Sep;29(3):146-150. doi: 10.1590/0102-6720201600030005.
The health benefits associated with moderate wine consumption, as with ethanol and phenolic compounds, include different mechanisms still little understandable.
Evaluate glycemic and weight variations, and the deposit of triglycerides, cholesterol and liver glycogen with red wine consumption.
60 ApoE knockout mice were divided into three groups of 20: Wine Group (WG), Ethanol Group (EG) and Water Group (WAG). They received daily: WG 50 ml of wine and 50 ml water; EG 6 ml ethanol and WAG 94 ml of water. All groups were followed for four months. The food intake was monitored daily, in the period from eight to ten hours and held every five days. The measurement of water intake was also made every five days. The weighing of the animals took place every ten days.
The WG had higher weight increase as compared to the other groups. The concentration of hepatic triglyceride was higher in WG (57%) and the EG group was lower (31.6%, p<0.01) than the control. The concentration of cholesterol was lower in the WG (23.6%), as well as EG (24.5%, p<0.05). The concentration of glycogen was higher in WG (16%) and fasting blood glucose was higher in EG compared to the other groups but not both demonstrated a statistically significant difference.
The WG increased triglyceride and WAG decreased cholesterol. The triglyceride may be increased due to the high caloric value of wine or some unknown property that led to significant increase in subcutaneous andretroperitoneal fat in mice.
与适量饮用葡萄酒相关的健康益处，如同乙醇和酚类化合物一样，其涉及的不同机制仍鲜为人知。
评估饮用红酒对血糖、体重变化以及甘油三酯、胆固醇和肝糖原沉积的影响。
将60只载脂蛋白E基因敲除小鼠分为三组，每组20只：红酒组（WG）、乙醇组（EG）和水对照组（WAG）。它们每天分别摄入：WG组50毫升葡萄酒和50毫升水；EG组6毫升乙醇；WAG组94毫升水。所有组均持续观察四个月。每天在8至10小时期间监测食物摄入量，每五天记录一次。每五天也测量一次水摄入量。每十天对动物进行称重。
与其他组相比，WG组体重增加更多。WG组肝脏甘油三酯浓度更高（57%），EG组更低（31.6%，p<0.01），与对照组相比有差异。WG组胆固醇浓度更低（23.6%），EG组也更低（24.5%，p<0.05）。WG组糖原浓度更高（16%），EG组空腹血糖高于其他组，但两者均未显示出统计学上的显著差异。
WG组甘油三酯增加，WAG组胆固醇降低。甘油三酯增加可能是由于葡萄酒的高热量值或某些未知特性导致小鼠皮下和腹膜后脂肪显著增加。
