Bauman Grzegorz, Santini Francesco, Pusterla Orso, Bieri Oliver
Division of Radiological Physics, Department of Radiology, University of Basel Hospital, Basel, Switzerland.
Deparment of Biomedical Engineering, University of Basel, Basel, Switzerland.
Magn Reson Med. 2017 Jan;77(1):74-82. doi: 10.1002/mrm.26490. Epub 2016 Oct 19.
To present a technique for simultaneous mapping of T , T , and relative spin density (M ) in human lung using inversion recovery ultra-fast steady-state free precession (IR-ufSSFP) imaging.
Pulmonary relaxometry with IR-ufSSFP is based on an interleaved time series acquisition of 2D images acquired at 1.5T. The technique was tested in a phantom and in four healthy volunteers using breath-hold and electrocardiogram triggering. Typically, 30 transient state images were acquired in a single breath-hold within < 10 s. From the signal time course, voxel-wise nonlinear fitting yielded T , T , and M parameter maps. Furthermore, off-resonance and B1 effects were investigated in a phantom.
In the phantom, the observed T of 829 ± 2 ms and T of 105 ± 4 ms were in agreement with the reference T of 858 ± 1 ms and T of 104 ± 1 ms using spin echo methods. In volunteers, the average T of 1375 ± 102 ms and T of 66 ± 26 ms of lung tissue were in good agreement with the literature and were observed to be independent of the respiratory phase. Overall, high reproducibility was shown in a volunteer, yielding coefficient of variations of 0.03 for M , 0.004 for T , and 0.04 for T measurements.
IR-ufSSFP allows for fast and simultaneous quantitative mapping of the human lung. Magn Reson Med 77:74-82, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
介绍一种使用反转恢复超快速稳态自由进动（IR-ufSSFP）成像技术同时对人体肺部的T1、T2和相对自旋密度（M）进行成像的方法。
基于IR-ufSSFP的肺部弛豫测量法是在1.5T条件下对二维图像进行交错时间序列采集。该技术在体模和四名健康志愿者身上进行了测试，采用屏气和心电图触发。通常，在一次屏气内<10秒采集30幅瞬态图像。从信号时间历程中，通过体素-wise非线性拟合得到T1、T2和M参数图。此外，在体模中研究了失谐和B1效应。
在体模中，观察到的T1为829±2毫秒，T2为105±4毫秒，与使用自旋回波方法得到的参考T1为858±1毫秒和T2为104±1毫秒一致。在志愿者中，肺组织的平均T1为1375±102毫秒，T2为66±26毫秒，与文献报道相符，且观察到与呼吸相位无关。总体而言，一名志愿者的重复性很高，M测量的变异系数为0.03，T1测量的变异系数为0.004，T2测量的变异系数为0.04。
IR-ufSSFP能够对人体肺部进行快速且同时的定量成像。《磁共振医学》77:74-82，2017年。©2016国际磁共振医学学会。
