De Luis Daniel A, Aller Rocío, Izaola Olatz, Primo David, Romero E
Centro de Investigación de Endocrinología y Nutrición. Medicine School. Universidad de Valladolid. Valladolid, Spain. Department of Endocrinology and Nutrition. Hospital Clínico Universitario de Valladolid. Valladolid.
Nutr Hosp. 2016 Sep 20;33(5):573. doi: 10.20960/nh.573.
The aim of our study was to analyze the relationship of the rs9939609 FTO gene polymorphism with insulin resistance and serum adipokine levels.
A population of 610 patients with obesity was analyzed in a cross sectional design. Weight, blood pressure, basal glucose, c-reactive protein (CRP), insulin, insulin resistance (HOMA), lipid profile and adipocytokines (leptin, adiponectin, resistin, TNF alpha, and interleukin 6) levels were measured.
Insulin (122.2 ± 101.8 pmol/L vs. 104.5 ± 61.5 pmol/L vs.112.1 ± 74.3 pmol/L:p < 0.05) and HOMA-IR values (4.76 ± 4.4 vs. 3.71 ± 2.5 vs.3.76 ± 3.1;p < 0.05) were higher in TT group than AT and AA groups. Triglycerides values were higher in TT group than AA group (1.42 ± 0.71 mmol/L vs.1.39 ± 0.69 mmol/L vs.1.23 ± 0.64 mmol/L;p < 0.05). Adiponectin levels were lower in TT genotype group than AA genotype group (35801.2 ± 35,912.3 ng/L vs.26,718.1 ± 36,323.1 ng/L vs. 21,112.3 ± 25,623.1 ng/L p < 0.05).
The FTO gene polymorphism, rs9939609, was found to be associated with insulin resistance, insulin, triglyceride and adiponectin levels in obese patients with TT variant.
我们研究的目的是分析FTO基因rs9939609位点多态性与胰岛素抵抗及血清脂肪因子水平之间的关系。
采用横断面设计对610例肥胖患者进行研究。测量体重、血压、基础血糖、C反应蛋白（CRP）、胰岛素、胰岛素抵抗（HOMA）、血脂谱及脂肪细胞因子（瘦素、脂联素、抵抗素、肿瘤坏死因子α和白细胞介素6）水平。
TT组胰岛素水平（122.2±101.8 pmol/L vs. 104.5±61.5 pmol/L vs.112.1±74.3 pmol/L：p<0.05）和HOMA-IR值（4.76±4.4 vs. 3.71±2.5 vs.3.76±3.1；p<0.05）高于AT组和AA组。TT组甘油三酯值高于AA组（1.42±0.71 mmol/L vs.1.39±0.69 mmol/L vs.1.23±0.64 mmol/L；p<0.05）。TT基因型组脂联素水平低于AA基因型组（35801.2±35912.3 ng/L vs.26718.1±36323.1 ng/L vs. 21112.3±25623.1 ng/L p<0.05）。
发现FTO基因多态性rs9939609与携带TT变异的肥胖患者的胰岛素抵抗、胰岛素、甘油三酯及脂联素水平相关。
