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rs9939609与体育锻炼无相互作用，但影响巴西超重和肥胖青少年的基础胰岛素代谢。

rs9939609 Does Not Interact with Physical Exercise but Influences Basal Insulin Metabolism in Brazilian Overweight and Obese Adolescents.

作者信息

do Nascimento Gabrielle Araujo, Leite Neiva, Furtado-Alle Lupe, Teixeira Mayza Dalcin, de Souza Ricardo Lehtonen Rodrigues, Milano Gerusa Eisfeld, da Silva Larissa Rosa, Pizzi Juliana, Lopes Wendell Arthur, Lopes Maria de Fátima Aguiar, Titski Ana Cláudia Kapp, Tureck Luciane Viater

机构信息

Department of Genetics, Centro Politécnico, Setor de Ciências Biológicas, Federal University of Paraná, Francisco H. dos Santos, 210 Jardim das Américas, 81531-970 Curitiba, PR, Brazil.

Department of Physical Education, Federal University of Paraná, Coração de Maria, 92 Jardim Botânico, 80215-370 Curitiba, PR, Brazil.

出版信息

J Obes. 2018 Apr 26;2018:3134026. doi: 10.1155/2018/3134026. eCollection 2018.

DOI:10.1155/2018/3134026
PMID:29854435
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5944237/
Abstract

PURPOSE

The rs9939609 SNP (T > A) in gene is associated with obesity and type 2 diabetes. The present study aimed at verifying whether this SNP influenced biochemical outcomes of children and adolescents who are overweight/obese submitted to a program of physical exercise and also if there was influence on basal levels of these biochemical variables.

METHODS

The sample was composed by 432 children and adolescents grouped in three ways (obese, overweight, and normal weight); of these, 135 children and adoloescents who are obese and overweight were submitted to a physical exercise program for 12 weeks. All were genotyped by TaqMan SNP genotyping assay.

RESULTS

The children and adolescents who are overweight/obese and carriers of AA genotype had higher levels of insulin (=0.03) and HOMA (=0.007) and lower levels of glucose (=0.003), but the SNP did not modulate the response to physical exercise.

CONCLUSIONS

In our study, the rs9939609 AA genotype was associated with parameters related to insulin metabolism but did not interact with physical exercise.

摘要

目的

基因中的rs9939609单核苷酸多态性（T＞A）与肥胖和2型糖尿病相关。本研究旨在验证该单核苷酸多态性是否影响接受体育锻炼计划的超重/肥胖儿童和青少年的生化指标，以及是否对这些生化变量的基础水平有影响。

方法

样本由432名儿童和青少年组成，分为三组（肥胖、超重和正常体重）；其中，135名肥胖和超重的儿童和青少年接受了为期12周的体育锻炼计划。所有参与者均通过TaqMan单核苷酸多态性基因分型检测进行基因分型。

结果

超重/肥胖且为AA基因型携带者的儿童和青少年胰岛素水平较高（=0.03）、胰岛素抵抗指数较高（=0.007），血糖水平较低（=0.003），但该单核苷酸多态性并未调节对体育锻炼的反应。

结论

在我们的研究中，rs9939609 AA基因型与胰岛素代谢相关参数有关，但与体育锻炼无相互作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6e5/5944237/ac8716301731/JOBE2018-3134026.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6e5/5944237/ac8716301731/JOBE2018-3134026.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6e5/5944237/ac8716301731/JOBE2018-3134026.001.jpg

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