Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan; Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan.
Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan; Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan.
Immunity. 2016 Oct 18;45(4):705-707. doi: 10.1016/j.immuni.2016.10.003.
TLRs play central roles in host defense. In this issue of Immunity, Zhang et al. (2016) generate structures of TLR7 bound to multiple ligands and provide insight into the mechanism of TLR7 ligand recognition that highlights the differences in the features of the TLR subfamily.
TLRs 在宿主防御中发挥核心作用。在本期《免疫》中，Zhang 等人（2016 年）生成了 TLR7 与多种配体结合的结构，并深入了解 TLR7 配体识别的机制，突出了 TLR 亚家族特征的差异。
