Boza Ayşen, Api Murat, Kayatas Semra, Ceyhan Mehmet, Boza Baris
a Department of Obstetrics and Gynecology , Goztepe Training and Research Hospital , Kadikoy , Istanbul , Turkey.
b Department of Obstetrics and Gynecology , Zeynep Kamil Maternity and Children's Training and Research Hospital , Istanbul , Turkey.
J Obstet Gynaecol. 2016 Nov;36(8):1076-1079. doi: 10.1080/01443615.2016.1205556. Epub 2016 Oct 20.
A prospective study was conducted to evaluate the effect of progestogens on the pregnancy outcome of threatened abortion (TA). A total of 251 pregnant women less than 20 weeks of gestational age (GA) were included. Group 1 consisted of women with vaginal bleeding who had already been under treatment with progestogens and Group 2 was composed of women with vaginal bleeding who were only followed without progestogen therapy, whereas Group 3 was the control group without any vaginal bleeding or progestogen therapy. The pregnancy outcomes and serum progesterone levels were compared among the groups. The mean serum progesterone concentrations were statistically significantly higher in Group 1 in comparison to Group 2 and 3 (p < 0.001). Abortion rates were similar among the study groups. Although progestogen supplementation leads to increased level of serum progesterone, this finding does not translate to its beneficial effect on the pregnancy outcomes in cases of TAs.
进行了一项前瞻性研究，以评估孕激素对先兆流产（TA）妊娠结局的影响。共纳入251例孕周小于20周的孕妇。第1组由已接受孕激素治疗的阴道出血妇女组成，第2组由仅接受观察而未接受孕激素治疗的阴道出血妇女组成，而第3组为无任何阴道出血或孕激素治疗的对照组。比较了各组的妊娠结局和血清孕酮水平。与第2组和第3组相比，第1组的平均血清孕酮浓度在统计学上显著更高（p<0.001）。各研究组的流产率相似。虽然补充孕激素会导致血清孕酮水平升高，但这一发现并未转化为其对先兆流产病例妊娠结局的有益影响。
