Miranda-Hernández D, Cruz-Reyes C, Monsebaiz-Mora C, Gómez-Bañuelos E, Ángeles U, Jara L J, Saavedra M Á
1 Rheumatology Department, Hospital de Especialidades Dr Antonio Fraga Mouret, Mexico City, Mexico.
2 Hospital General Regional No. 1, Charo, Mexico.
Lupus. 2017 May;26(6):640-645. doi: 10.1177/0961203316672926. Epub 2016 Oct 18.
The aim of this study was to estimate the impact of the haematological manifestations of systemic lupus erythematosus (SLE) on mortality in hospitalized patients. For that purpose a case-control study of hospitalized patients in a medical referral centre from January 2009 to December 2014 was performed. For analysis, patients hospitalized for any haematological activity of SLE ( n = 103) were compared with patients hospitalized for other manifestations of SLE activity or complications of treatment ( n = 206). Taking as a variable outcome hospital death, an analysis of potential associated factors was performed. The most common haematological manifestation was thrombocytopenia (63.1%), followed by haemolytic anaemia (30%) and neutropenia (25.2%). In the group of haematological manifestations, 17 (16.5%) deaths were observed compared to 10 (4.8%) deaths in the control group ( P < 0.001). The causes of death were similar in both groups. In the analysis of the variables, it was found that only haematological manifestations were associated with intra-hospital death (odds ratio 3.87, 95% confidence interval 1.8-88, P < 0.001). Our study suggests that apparently any manifestation of haematological activity of SLE is associated with poor prognosis and contributes to increased hospital mortality.
本研究旨在评估系统性红斑狼疮（SLE）血液学表现对住院患者死亡率的影响。为此，对2009年1月至2014年12月在一家医疗转诊中心住院的患者进行了病例对照研究。为进行分析，将因SLE任何血液学活动住院的患者（n = 103）与因SLE活动的其他表现或治疗并发症住院的患者（n = 206）进行比较。将住院死亡作为可变结局，对潜在相关因素进行了分析。最常见的血液学表现是血小板减少症（63.1%），其次是溶血性贫血（30%）和中性粒细胞减少症（25.2%）。在血液学表现组中，观察到17例（16.5%）死亡，而对照组为10例（4.8%）死亡（P < 0.001）。两组的死亡原因相似。在变量分析中，发现只有血液学表现与院内死亡相关（比值比3.87，95%置信区间1.8 - 88，P < 0.001）。我们的研究表明，显然SLE血液学活动的任何表现都与预后不良相关，并导致医院死亡率增加。
