Department of Rheumatology, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon, 16499, Korea.
Department of Biomedical Informatics, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon, 16499, Korea.
Sci Rep. 2019 Jul 4;9(1):9704. doi: 10.1038/s41598-019-46039-5.
Infection occurs frequently in patients with systemic lupus erythematosus (SLE), and has been a major cause of morbidity and mortality. However, no large-scale comprehensive studies have estimated the effect of clinical characteristics on serious infection in actual clinical practice yet. We investigated the influence of clinical characteristics on serious infections using electronic medical records data. We conducted a nested case-control study. Patients with SLE who developed serious infection which needs hospitalization or intravenous antibiotics (n = 120) were matched to controls (n = 240) who didn't. Odds ratios (OR) and 95% confidence intervals (CIs) for infection associated with clinical features were obtained by conditional logistic regression analyses. The conditional logistic regression analysis with adjustment showed that serositis (OR, 2.76; 95% CI, 1.33-5.74), hematologic involvement (OR, 2.53; 95% CI, 1.32-4.87), and use of higher than the low dose of glucocorticoids (GCs; >7.5 mg/d prednisolone-equivalent) (OR, 2.65; 95% CI, 1.31-5.34) were related to serious infections in SLE. Serositis, hematologic involvement, and use of higher than the low dose of GCs were associated with serious infections in patients with SLE.
感染在系统性红斑狼疮（SLE）患者中很常见，是发病率和死亡率的主要原因。然而，目前还没有大规模的综合研究来评估临床特征对实际临床实践中严重感染的影响。我们使用电子病历数据调查了临床特征对严重感染的影响。我们进行了一项巢式病例对照研究。将发生严重感染（需要住院或静脉使用抗生素）的 SLE 患者（n=120）与未发生严重感染的对照患者（n=240）进行匹配。通过条件逻辑回归分析获得与感染相关的临床特征的比值比（OR）和 95%置信区间（CI）。调整后的条件逻辑回归分析显示，浆膜炎（OR，2.76；95%CI，1.33-5.74）、血液学受累（OR，2.53；95%CI，1.32-4.87）和使用高于低剂量糖皮质激素（GCs；>7.5mg/d 泼尼松龙等效物）（OR，2.65；95%CI，1.31-5.34）与 SLE 患者的严重感染有关。浆膜炎、血液学受累和使用高于低剂量 GCs 与 SLE 患者的严重感染有关。
