Rose P G, Piver M S, Tsukada Y, Lau T S
Department of Gynecologic Oncology and Pathology, Roswell Park Memorial Institute, Buffalo, New York 14263.
Cancer. 1989 Oct 1;64(7):1508-13. doi: 10.1002/1097-0142(19891001)64:7<1508::aid-cncr2820640725>3.0.co;2-v.
The autopsy findings of 428 patients with various histologic types of ovarian cancer were studied to determine if metastatic patterns were different. Epithelial tumors were the most frequent (89%), followed by sarcomas (7.2%). Germ cell and stromal tumors each occurred in 1.9% of cases. Sites of metastasis were nearly identical, with no statistical difference among histologic types. The peritoneum was most frequently involved (83% to 100% of cases), but lymph node metastasis was common (50% to 60% of cases). Metastasis was more common to the paraaortic lymph nodes than to the pelvic lymph nodes. In seven of eight stromal tumors, hepatic metastasis was present but did not cause the patient's death. For epithelial tumors, metastasis to distant sites was dependent on nodal and intraperitoneal disease. However, this was not true in the 31 ovarian sarcomas or the series of germ cell or stromal tumors. This finding supports a hematogenous route of metastasis for ovarian sarcomas. Understanding the metastatic potential of ovarian cancer is important in designing effective treatment regimens.
对428例不同组织学类型的卵巢癌患者的尸检结果进行研究，以确定转移模式是否存在差异。上皮性肿瘤最为常见（89%），其次是肉瘤（7.2%）。生殖细胞肿瘤和性索间质肿瘤各占病例的1.9%。转移部位几乎相同，不同组织学类型之间无统计学差异。腹膜受累最为常见（83%至100%的病例），但淋巴结转移也很常见（50%至60%的病例）。转移至腹主动脉旁淋巴结比盆腔淋巴结更常见。在8例性索间质肿瘤中的7例中，存在肝转移，但未导致患者死亡。对于上皮性肿瘤，远处转移取决于淋巴结和腹腔内病变。然而，在31例卵巢肉瘤或生殖细胞肿瘤或性索间质肿瘤系列中并非如此。这一发现支持卵巢肉瘤的血行转移途径。了解卵巢癌的转移潜能对于设计有效的治疗方案很重要。
