Chang H R, Hajdu S I, Collin C, Brennan M F
Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
Cancer. 1989 Oct 1;64(7):1514-20. doi: 10.1002/1097-0142(19891001)64:7<1514::aid-cncr2820640726>3.0.co;2-2.
Patients with a localized primary liposarcoma of the extremity who were treated in Memorial Sloan-Kettering Cancer Center between 1968 and 1978 were studied. The prognosis of patients with extremity liposarcoma was analyzed according to histopathologic subtypes. A system of five subtypes was used; well-differentiated, myxoid, fibroblastic, lipoblastic, and pleomorphic liposarcomas. The 5-year treatment failure rates and survival rates were, respectively, 30% and 100% for well-differentiated, 25% and 88% for myxoid, 60% and 58% for fibroblastic, 100% and 40% for lipoblastic, and 64% and 56% for pleomorphic liposarcomas. Although local recurrence was present in all five subtypes, a significant increment in local failure was seen in patients with high-grade liposarcomas. Distant metastasis after the initial operation was not found in patients with well-differentiated liposarcoma and rare in the patients with myxoid liposarcoma. In contrast, 50% of the patients with fibroblastic, lipoblastic, and pleomorphic liposarcoma had a distant relapse within 5 years.
对1968年至1978年间在纪念斯隆凯特琳癌症中心接受治疗的局限性肢体原发性脂肪肉瘤患者进行了研究。根据组织病理学亚型分析了肢体脂肪肉瘤患者的预后。采用了一个包含五个亚型的系统；高分化型、黏液型、纤维母细胞型、脂肪母细胞型和多形性脂肪肉瘤。高分化型脂肪肉瘤的5年治疗失败率和生存率分别为30%和100%，黏液型分别为25%和88%，纤维母细胞型分别为60%和58%，脂肪母细胞型分别为100%和40%，多形性脂肪肉瘤分别为64%和56%。尽管所有五个亚型均存在局部复发，但高级别脂肪肉瘤患者的局部失败有显著增加。高分化型脂肪肉瘤患者初次手术后未发现远处转移，黏液型脂肪肉瘤患者中也很少见。相比之下，纤维母细胞型、脂肪母细胞型和多形性脂肪肉瘤患者中有50%在5年内出现远处复发。
