Tfayli Yehia, Baydoun Ahmad, Naja Ahmad Salaheddine, Saghieh Said
Division of Orthopedic Surgery, Department of Surgery, American University of Beirut Medical Center, 11-0236 Beirut, Lebanon.
Department of Surgery, Saint George Hospital University Medical Center, University of Balamand, 11-0236 Beirut, Lebanon.
Oncol Lett. 2021 Aug;22(2):596. doi: 10.3892/ol.2021.12857. Epub 2021 Jun 9.
Myxoid liposarcoma (MLPS) is the second most common type of LPS after the well differentiated LPS. MLPS is primarily localized to the extremities. The incidence of LPS is ~2 per million worldwide. MLPS accounts for ~30% of all LPS cases. MLPS is usually encountered in adults, but can also occur in younger individuals more than other types of LPS. MLPS can be divided into low- and high-grade subtypes, which present with differences in patient prognosis and outcome. Methods of tumor management include surgery, radiotherapy and chemotherapy; however, there is no unified treatment based on tumor characteristics alone. The present manuscript reviews the surgical management, radiotherapeutic and chemotherapeutic approaches reported in the literature for different types of MLPS in the extremities, as well as the post-treatment outcomes. In addition, the present review provides an evidence-based management plan for MLPS in the form of an organogram based on specific tumor and patient parameters.
黏液样脂肪肉瘤（MLPS）是继高分化脂肪肉瘤之后第二常见的脂肪肉瘤类型。MLPS主要位于四肢。脂肪肉瘤在全球的发病率约为百万分之二。MLPS约占所有脂肪肉瘤病例的30%。MLPS通常发生于成年人，但与其他类型的脂肪肉瘤相比，也可发生于较年轻的个体。MLPS可分为低级别和高级别亚型，这两种亚型在患者预后和结局方面存在差异。肿瘤治疗方法包括手术、放疗和化疗；然而，目前尚无仅基于肿瘤特征的统一治疗方案。本文综述了文献中报道的针对四肢不同类型MLPS的手术治疗、放射治疗和化学治疗方法，以及治疗后的结局。此外，本综述以基于特定肿瘤和患者参数的组织图形式，为MLPS提供了一个循证管理计划。
