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来自西伯利亚一名HIV阳性患者的北京B0/W谱系B9741菌株的基因组序列草图

Draft genome sequence of strain B9741 of Beijing B0/W lineage from HIV positive patient from Siberia.

作者信息

Shur K V, Zaychikova M V, Mikheecheva N E, Klimina K M, Bekker O B, Zhdanova S N, Ogarkov O B, Danilenko V N

机构信息

Laboratory of Bacterial Genetics, Vavilov Institute of General Genetics (VIGG RAS), Gubkina str. 3, 119991 Moscow, Russia.

Scientific Centre for Family Health and Human Reproduction Problems (SCFHHRP), Irkutsk, Russia.

出版信息

Genom Data. 2016 Aug 3;10:61-62. doi: 10.1016/j.gdata.2016.08.001. eCollection 2016 Dec.

DOI:10.1016/j.gdata.2016.08.001
PMID:27761405
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5064989/
Abstract

We report a draft genome sequence of strain B9741 belonging to Beijing B0/W lineage isolated from a HIV patient from Siberia, Russia. This clinical isolate showed MDR phenotype and resistance to isoniazid, rifampin, streptomycin and pyrazinamide. We analyzed SNPs associated with virulence and resistance. The draft genome sequence and annotation have been deposited at GenBank under the accession NZ_LVJJ00000000.

摘要

我们报告了从俄罗斯西伯利亚一名艾滋病患者分离出的属于北京B0/W谱系的菌株B9741的基因组序列草图。该临床分离株表现出多重耐药表型,对异烟肼、利福平、链霉素和吡嗪酰胺耐药。我们分析了与毒力和耐药性相关的单核苷酸多态性。该基因组序列草图及注释已提交至GenBank,登录号为NZ_LVJJ00000000。

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本文引用的文献

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Mycobacterium tuberculosis Type II Toxin-Antitoxin Systems: Genetic Polymorphisms and Functional Properties and the Possibility of Their Use for Genotyping.结核分枝杆菌II型毒素-抗毒素系统:遗传多态性、功能特性及其用于基因分型的可能性
PLoS One. 2015 Dec 14;10(12):e0143682. doi: 10.1371/journal.pone.0143682. eCollection 2015.
2
[The virulence factors of Mycobacterium tuberculosis: genetic control, new conceptions].[结核分枝杆菌的毒力因子:基因控制,新观念]
Genetika. 2014 Aug;50(8):885-908.
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Multiple toxin-antitoxin systems in Mycobacterium tuberculosis.结核分枝杆菌中的多种毒素-抗毒素系统。
Toxins (Basel). 2014 Mar 6;6(3):1002-20. doi: 10.3390/toxins6031002.
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Clade-specific virulence patterns of Mycobacterium tuberculosis complex strains in human primary macrophages and aerogenically infected mice.结核分枝杆菌复合群菌株在人原代巨噬细胞和空气感染小鼠中的种系特异性毒力模式。
mBio. 2013 Jul 30;4(4):e00250-13. doi: 10.1128/mBio.00250-13.
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Russian "successful" clone B0/W148 of Mycobacterium tuberculosis Beijing genotype: a multiplex PCR assay for rapid detection and global screening.俄罗斯“成功”克隆的结核分枝杆菌北京基因型 B0/W148:一种快速检测和全球筛查的多重 PCR 检测方法。
J Clin Microbiol. 2012 Nov;50(11):3757-9. doi: 10.1128/JCM.02001-12. Epub 2012 Aug 29.
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High resolution discrimination of clinical Mycobacterium tuberculosis complex strains based on single nucleotide polymorphisms.基于单核苷酸多态性的临床结核分枝杆菌复合群菌株的高分辨率鉴别。
PLoS One. 2012;7(7):e39855. doi: 10.1371/journal.pone.0039855. Epub 2012 Jul 2.
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PLoS One. 2008 May 7;3(5):e2087. doi: 10.1371/journal.pone.0002087.
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The PIN-domain toxin-antitoxin array in mycobacteria.分枝杆菌中的PIN结构域毒素-抗毒素阵列
Trends Microbiol. 2005 Aug;13(8):360-5. doi: 10.1016/j.tim.2005.06.008.
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