Moerke Caroline, Mueller Petra, Nebe Barbara
University Medical Center Rostock, Department of Cell Biology, Rostock, Germany.
Data Brief. 2016 Feb 17;7:177-182. doi: 10.1016/j.dib.2016.02.023. eCollection 2016 Jun.
The provided data contains the phagocytic interaction of human MG-63 osteoblasts with micro-particles 6 µm in size as well as geometric micro-pillared topography with micro-pillar sizes 5 µm of length, width, height and spacing respectively related to the research article entitled "Attempted caveolae-mediated phagocytosis of surface-fixed micro-pillars by human osteoblasts" in the journal. [1] Micro-particle treatment was used as positive control triggering phagocytosis by the osteoblasts. Caveolin-1 (Cav-1) as major structural component of caveolae [2] plays an important role in the phagocytic process of micro-particles and -pillars. Data related to the experiments in [1] with siRNA-mediated knockdown are presented here as well as micro-particle control experiments, tubulin analysis on the micro-pillared topography and initial cell interaction with the micro-pillars.
所提供的数据包含人类MG-63成骨细胞与6微米大小的微粒以及几何微柱形貌之间的吞噬相互作用，微柱的长度、宽度、高度和间距均为5微米，这与期刊上题为《人类成骨细胞对表面固定微柱的小窝介导吞噬作用的尝试》的研究文章相关。[1]微粒处理用作触发成骨细胞吞噬作用的阳性对照。小窝蛋白-1（Cav-1）作为小窝的主要结构成分[2]，在微粒和微柱的吞噬过程中起重要作用。这里展示了与[1]中siRNA介导的敲低实验相关的数据，以及微粒对照实验、微柱形貌上的微管蛋白分析和细胞与微柱的初始相互作用。
