Lancaster L D, Kern K B, Morrison D A, Olajos M, Goldman S
Department of Internal Medicine, Tucson, Arizona.
Cardiovasc Res. 1989 Jan;23(1):46-52. doi: 10.1093/cvr/23.1.46.
To determine the effect of an anteroseptal myocardial infarction on right ventricular systolic and diastolic function, we studied 12 pigs before and 1 h after left anterior descending coronary artery occlusion. Total arterial occlusion was achieved by the percutaneous, transcatheter placement of a 1 mm Teflon plug into the mid portion of the artery. The resulting infarction involved 28 (SEM 3)% of the left ventricular wall, in the anterior and septal regions. A small rim of the right ventricular free wall adjacent to the septum and the right ventricular apex were also affected. End diastolic pressures in both ventricles rose significantly: left ventricular from 12(1) to 20(2) mm Hg and right ventricular from 8(1) to 10(1) mm Hg. Right ventricular peak systolic pressure increased from 29(2) to 35(2) mm Hg while left ventricular peak systolic pressure did not change. One hour after infarction the half time of isovolumic relaxation of the right ventricle was prolonged from 6.9(0.5) to 8.7(0.4) ms. Ejection fraction in both ventricles was depressed: from 46(1) to 34(2)% in the right ventricle and from 69(3) to 49(3) in the left ventricle. There was no change in either right or left ventricular dP/dt. These data suggest that right ventricular systolic and diastolic dysfunction occurs as the result of an anteroseptal myocardial infarction in pigs.
为了确定前间隔心肌梗死对右心室收缩和舒张功能的影响，我们在12头猪左前降支冠状动脉闭塞前和闭塞后1小时进行了研究。通过经皮经导管将一个1毫米的聚四氟乙烯栓塞置于动脉中部实现完全动脉闭塞。由此产生的梗死累及左心室壁前壁和间隔区域的28（标准误3）%。紧邻间隔的右心室游离壁小边缘及右心室心尖也受到影响。两个心室的舒张末期压力均显著升高：左心室从12（1）毫米汞柱升至20（2）毫米汞柱，右心室从8（1）毫米汞柱升至10（1）毫米汞柱。右心室收缩压峰值从29（2）毫米汞柱升至35（2）毫米汞柱，而左心室收缩压峰值未改变。梗死后1小时，右心室等容舒张半衰期从6.9（0.5）毫秒延长至8.7（0.4）毫秒。两个心室的射血分数均降低：右心室从46（1）%降至34（2）%，左心室从69（3）%降至49（3）%。右心室和左心室的dP/dt均无变化。这些数据表明，猪的前间隔心肌梗死会导致右心室收缩和舒张功能障碍。
