Brooks H, Al-Sadir J, Schwartz J, Rich B, Harper P, Resnekov L
Am J Cardiol. 1975 Nov;36(6):765-75. doi: 10.1016/0002-9149(75)90458-0.
The porcine heart has been shown to have close anatomic similarity to the human heart and was used as the experimental model in this study to gain further understanding of the early responses of both ventricles during acute anteroseptal myocardial infarction. High fidelity pressure and flow data were measured and multiple preejection and ejection variables were calculated for both ventricles. Infarct weight and distribution in both ventricles were quantitated. The standard infarction resulted from single stage ligation of the left anterior descending coronary artery just beyond its midpoint and second left ventricular branch. It comprised an average of 15.8 percent of total ventricular myocardium with an infarct/perfused ratio of 0.62 and a periinfarction transition zone of 7.5 mm, and involved significant portions of both ventricles and the interventricular septum. Performance characteristics of both ventricles were altered significantly by anteroseptal infarction and involved all phases of contraction--end-diastole, isovolumic systole and ventricular ejection. Although contractile alterations in the right ventricle were significant, they were somewhat delayed, yielding relatively low correlation coefficients with analogous left ventricular contractile indexes. These correlations became quite distinct during specific ventricular stresses. Comparison of anterolateral and anteroseptal infarction, matched in terms of infarct size, indicated that the right ventricular changes in the latter were related to direct involvement of the right ventricular free wall and septum rather than secondary to left ventricular alterations.
猪心脏已被证明在解剖结构上与人类心脏非常相似，在本研究中被用作实验模型，以进一步了解急性前间隔心肌梗死期间两个心室的早期反应。测量了高保真压力和流量数据，并计算了两个心室的多个射血前期和射血变量。对两个心室的梗死重量和分布进行了定量分析。标准梗死是通过在左前降支冠状动脉中点和第二左心室分支之外进行单阶段结扎造成的。它平均占心室总心肌的15.8%，梗死/灌注比为0.62，梗死周围过渡区为7.5毫米，累及两个心室和室间隔的大部分。前间隔梗死显著改变了两个心室的性能特征，涉及收缩的所有阶段——舒张末期、等容收缩期和心室射血期。虽然右心室的收缩改变很显著，但有些延迟，与类似的左心室收缩指标的相关系数相对较低。在特定的心室应激期间，这些相关性变得非常明显。对梗死面积匹配的前外侧梗死和前间隔梗死进行比较表明，后者右心室的变化与右心室游离壁和室间隔的直接受累有关，而不是继发于左心室的改变。
