日本HIV感染患者尿肝型脂肪酸结合蛋白与慢性肾脏病分级之间的关联
The association between urinary liver-type fatty acid-binding protein and chronic kidney disease classification in HIV-infected Japanese patients.
作者信息
Hikasa Shinichi, Yasuda Megumi, Hideta Kyoko, Kawakami Mai, Higasa Satoshi, Sawada Akihiro, Tokugawa Tazuko, Kimura Takeshi
机构信息
Department of Pharmacy, The Hospital of Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan.
Department of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, Kobe, Japan.
出版信息
Clin Exp Nephrol. 2017 Dec;21(6):971-977. doi: 10.1007/s10157-016-1347-8. Epub 2016 Oct 19.
BACKGROUND
Renal dysfunction is recognized with increasing frequency among the noninfectious comorbidities associated with human immunodeficiency virus (HIV) infection. Urinary liver-type fatty acid-binding protein (L-FABP) has been shown to be a new biomarker to screen for not only tubulointerstitial damage but also kidney dysfunction.
METHODS
We performed a cross-sectional study to determine the association between the urinary L-FABP and chronic kidney disease (CKD) among 77 HIV-infected Japanese patients by backward-stepwise multivariable logistic regression.
RESULTS
The prevalence of individuals in the low risk was 80 %. Urinary L-FABP level was not associated with antiretroviral therapy and tenofovir disoproxil fumarate. On the other hand, urinary L-FABP level was independently associated with the CKD classification.
CONCLUSION
Urinary L-FABP may be used as an adjunct to diagnose the CKD stage.
背景
在与人类免疫缺陷病毒（HIV）感染相关的非感染性合并症中，肾功能障碍的识别频率越来越高。尿肝型脂肪酸结合蛋白（L-FABP）已被证明是一种不仅可用于筛查肾小管间质损伤，还可用于筛查肾功能障碍的新型生物标志物。
方法
我们进行了一项横断面研究，通过向后逐步多变量逻辑回归分析，确定77例感染HIV的日本患者中尿L-FABP与慢性肾脏病（CKD）之间的关联。
结果
低风险个体的患病率为80%。尿L-FABP水平与抗逆转录病毒治疗及替诺福韦酯无关。另一方面，尿L-FABP水平与CKD分级独立相关。
结论
尿L-FABP可作为诊断CKD分期的辅助手段。
Zotero 插件