皮肤类固醇生成在健康和疾病中的作用。
Skin steroidogenesis in health and disease.
机构信息
Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Auenweg 38, 06847, Dessau, Germany.
Section on Endocrinology and Genetics, NICHD, NIH, Bethesda, MD, USA.
出版信息
Rev Endocr Metab Disord. 2016 Sep;17(3):247-258. doi: 10.1007/s11154-016-9390-z.
The skin is an important extra-gonadal steroidogenic organ, capable of metabolizing various hormones from their precursors, as well as of synthesizing de novo a broad palette of sex steroids and glucocorticoids from cholesterol. In this manuscript, we review the major steroidogenic properties of human skin and we suggest steroidogenesis' impairment as a cardinal factor for various pathological conditions such as acne, rosacea, atopic dermatitis, and androgenic alopecia.
皮肤是一个重要的性腺外甾体生成器官，能够将各种激素从其前体代谢转化，还能够从头合成广泛的类固醇性激素和糖皮质激素。在本文中，我们回顾了人类皮肤的主要甾体生成特性，并提出甾体生成障碍是痤疮、酒渣鼻、特应性皮炎和雄激素性脱发等各种病理状况的主要因素。
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