Sturges Camille I, Jain Shivani, Velasquez Mauricio, Gedamu Hanna, Komarovsky Jessica, McDonald Jeffrey, Harris-Tryon Tamia
Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, Texas, USA; Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
J Invest Dermatol. 2025 Aug;145(8):1850-1857. doi: 10.1016/j.jid.2025.05.013. Epub 2025 Jun 14.
The skin can generate hormones through de novo steroid hormone synthesis. These hormones have been shown to play a significant role in inflammatory skin conditions through the regulation of skin immunity, sebum production, and skin barrier function. Although there is growing interest in understanding the composition and function of skin hormones throughout the human lifespan and in various pathologies, there remains a need to standardize sampling and quantification methods. In this article, we discuss an emerging noninvasive approach in skin hormone quantification through adhesive sebum collection tape followed by analysis through mass spectrometry or hormone-specific immunoassays. This approach is highly adaptable, allowing for repetitive sampling over time and across diverse study populations.
皮肤可通过从头合成类固醇激素来产生激素。这些激素已被证明通过调节皮肤免疫、皮脂分泌和皮肤屏障功能，在炎症性皮肤病中发挥重要作用。尽管人们对了解皮肤激素在人类整个生命周期和各种病理状态下的组成和功能的兴趣日益浓厚，但仍需要对采样和定量方法进行标准化。在本文中，我们讨论了一种新兴的非侵入性方法，即通过粘性皮脂收集带进行皮肤激素定量，然后通过质谱分析或激素特异性免疫测定法进行分析。这种方法具有高度的适应性，允许随时间推移和在不同研究人群中进行重复采样。
