Prayudi Pande Kadek Aditya, Permatasari Anak Agung Istri Yulan, Winata I Gde Sastra, Suwiyoga Ketut
Department of Obstetrics and Gynecology, Sanglah General Hospital/Faculty of Medicine, Udayana University, Denpasar, Bali, Indonesia.
J Obstet Gynaecol Res. 2016 Dec;42(12):1829-1838. doi: 10.1111/jog.13123. Epub 2016 Oct 20.
To determine the impact of human papilloma virus (HPV) vaccination on knowledge, perception of sexual risk and need for continued safe sexual behavior among Indonesian girls.
A comparative cross-sectional study was carried on in Denpasar, the capital city of Bali, Indonesia, during September 2015-February 2016. A total of 828 adolescent girls (12-16 years) were recruited to assess their knowledge on HPV/HPV vaccine, perception of sexual risks and need for continued safe sexual behavior.
A total of 419 girls (50.7%) had received HPV vaccination prior to the study, 76.4% of whom (320/419) had sufficient knowledge about HPV. HPV vaccination was a strong and independent predictor of higher HPV/HPV vaccine knowledge (adjusted OR [AOR], 9.358; 95%CI: 6.816-12.849, P < 0.001). HPV vaccination (AOR, 0.107; 95%CI: 0.074-0.155, P < 0.001) and higher knowledge level (AOR, 0.667; 95%CI: 0.464-0.958, P = 0.028) were associated with lower perceived HPV risk. Despite the low risk perception, most of the vaccinated girls (408/419, 97.4%) continued to perceive higher need for safe sexual behaviors. On multivariate analysis, higher knowledge was the independent predictor for higher perceived need for safe sexual behaviors (AOR, 4.260; 95%CI: 2.016-9.001, P < 0.001).
The HPV vaccination was associated with higher knowledge and appropriately lower perception of HPV risk. Despite the vaccination, most of the adolescents continued to perceive a need for safer sexual behavior. All adolescent girls should receive HPV vaccination in order to reduce cervical cancer burden in the future.
确定人乳头瘤病毒（HPV）疫苗接种对印度尼西亚女孩的知识水平、性风险认知以及持续进行安全性行为需求的影响。
2015年9月至2016年2月期间，在印度尼西亚巴厘岛首府登巴萨开展了一项比较性横断面研究。共招募了828名青春期女孩（12 - 16岁），以评估她们对HPV/HPV疫苗的知识、性风险认知以及持续进行安全性行为的需求。
共有419名女孩（50.7%）在研究前接种了HPV疫苗，其中76.4%（320/419）对HPV有足够的了解。HPV疫苗接种是HPV/HPV疫苗知识水平较高的一个强有力的独立预测因素（调整后的比值比[AOR]，9.358；95%置信区间：6.816 - 12.849，P < 0.001）。HPV疫苗接种（AOR，0.107；95%置信区间：0.074 - 0.155，P < 0.001）和较高的知识水平（AOR，0.667；95%置信区间：0.464 - 0.958，P = 0.028）与较低的HPV风险认知相关。尽管风险认知较低，但大多数接种疫苗的女孩（408/419，97.4%）仍然认为有更高的安全性行为需求。在多变量分析中，较高的知识水平是安全性行为需求认知较高的独立预测因素（AOR，4.260；95%置信区间：2.016 - 9.001，P < 0.001）。
HPV疫苗接种与较高的知识水平以及适当降低的HPV风险认知相关。尽管接种了疫苗，但大多数青少年仍然认为有进行更安全性行为的需求。所有青春期女孩都应接种HPV疫苗，以减轻未来宫颈癌的负担。
