Turiho Andrew Kampikaho, Muhwezi Wilson Winston, Okello Elialilia Sarikiaeli, Tumwesigye Nazarius Mbona, Banura Cecil, Katahoire Anne Ruhweza
Department of Psychiatry, School of Medicine, Makerere University, Kampala, Uganda.
School of Public Health, Makerere University, Kampala, Uganda.
PLoS One. 2015 Sep 1;10(9):e0137094. doi: 10.1371/journal.pone.0137094. eCollection 2015.
The purpose of the study was to investigate the influence of human papillomavirus (HPV) vaccination on adolescent girls' knowledge of HPV and HPV vaccine, perception of sexual risk and intentions for sexual debut. This cross-sectional comparative study was conducted in Ibanda and Mbarara districts. Data was collected using a standardized self-administered questionnaire and analyzed using the Statistical Package for the Social Sciences computer software. Univariate, bivariate, and logistic regression analyses were conducted with significance level set at p < .05. Results showed that HPV vaccination was associated with being knowledgeable (Crude OR: 5.26, CI: 2.32-11.93; p = 0.000). Vaccination against HPV did not predict perception of sexual risk. Knowledge was low (only 87/385 or 22.6% of vaccinated girls were knowledgeable), but predicted perception of a high sexual risk (Adjusted OR: 3.12, CI: 1.37-3.63; p = 0.008). HPV vaccination, knowledge and perceived sexual risk did not predict sexual behaviour intentions. High parental communication was associated with adolescent attitudes that support postponement of sexual debut in both bivariate and multiple regression analyses. In conclusion, findings of this study suggest that HPV vaccination is not likely to encourage adolescent sexual activity. Influence of knowledge on sexual behaviour intentions was not definitively explained. Prospective cohort studies were proposed to address the emerging questions.
该研究的目的是调查人乳头瘤病毒（HPV）疫苗接种对青春期女孩关于HPV及HPV疫苗的知识、性风险认知和首次性行为意向的影响。这项横断面比较研究在伊班达区和姆巴拉拉区开展。数据通过标准化的自填式问卷收集，并使用社会科学统计软件包进行分析。进行了单变量、双变量和逻辑回归分析，显著性水平设定为p < 0.05。结果显示，HPV疫苗接种与知识丰富相关（粗比值比：5.26，可信区间：2.32 - 11.93；p = 0.000）。HPV疫苗接种并不能预测对性风险的认知。知识水平较低（在接种疫苗的女孩中，只有87/385或22.6%知识丰富），但能预测对高性风险的认知（调整后比值比：3.12，可信区间：1.37 - 3.63；p = 0.008）。HPV疫苗接种、知识和感知到的性风险并不能预测性行为意向。在双变量和多元回归分析中，父母与孩子的高沟通频率与支持推迟首次性行为的青少年态度相关。总之，本研究结果表明HPV疫苗接种不太可能鼓励青少年进行性活动。知识对性行为意向的影响尚未得到确切解释。建议开展前瞻性队列研究以解决新出现的问题。
