Cheung C K, Lao T, Swaminathan R
Department of Chemical Pathology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N.T.
Clin Chem. 1989 Sep;35(9):1978-80.
Total protein (TP), albumin (Alb), transferrin (TRF), retinol-binding protein (RPB), N-acetyl-beta-glucosaminidase (NAG), alanine aminopeptidase (AAP), gamma-glutamyltransferase (GGT), and creatinine (Cr) were measured in random (untimed) urine samples from 29 nonpregnant women and from pregnant subjects (11 in the first trimester, 34 in the second, and 37 in the third). The excretion of TP, Alb, TRF, NAG, and AAP (relative to creatinine) and the RBP concentration were all higher (P less than or equal to 0.05) in the second and third trimesters compared with values for the nonpregnant controls. The GGT/Cr ratio was significantly higher only in the third trimester. The increase in low-molecular-mass proteins and tubular enzymes suggests that at least part of the increase in Alb, TRF, and TP results from decreased tubular reabsorption. We conclude that excretion of both high- and low-molecular-mass proteins is increased during pregnancy.
在29名未怀孕女性以及怀孕女性（孕早期11名、孕中期34名、孕晚期37名）的随机（不定时）尿液样本中检测了总蛋白（TP）、白蛋白（Alb）、转铁蛋白（TRF）、视黄醇结合蛋白（RPB）、N - 乙酰 - β - 氨基葡萄糖苷酶（NAG）、丙氨酸氨基肽酶（AAP）、γ - 谷氨酰转移酶（GGT）和肌酐（Cr）。与未怀孕对照组相比，孕中期和孕晚期TP、Alb、TRF、NAG和AAP的排泄量（相对于肌酐）以及RPB浓度均更高（P≤0.05）。仅在孕晚期GGT/Cr比值显著更高。低分子量蛋白质和肾小管酶的增加表明，Alb、TRF和TP的增加至少部分是由于肾小管重吸收减少所致。我们得出结论，孕期高分子量和低分子量蛋白质的排泄均增加。
