小鼠多瘤病毒感染中的基因调控与质量控制
Gene Regulation and Quality Control in Murine Polyomavirus Infection.
作者信息
Carmichael Gordon G
机构信息
Department of Genetics and Genome Sciences, UCONN Health, Farmington, CT 06030, USA.
出版信息
Viruses. 2016 Oct 17;8(10):284. doi: 10.3390/v8100284.
Murine polyomavirus (MPyV) infects mouse cells and is highly oncogenic in immunocompromised hosts and in other rodents. Its genome is a small, circular DNA molecule of just over 5000 base pairs and it encodes only seven polypeptides. While seemingly simply organized, this virus has adopted an unusual genome structure and some unusual uses of cellular quality control pathways that, together, allow an amazingly complex and varied pattern of gene regulation. In this review we discuss how MPyV leverages these various pathways to control its life cycle.
小鼠多瘤病毒（MPyV）感染小鼠细胞，在免疫功能低下的宿主和其他啮齿动物中具有高度致癌性。其基因组是一个略超过5000个碱基对的小型环状DNA分子，仅编码七种多肽。虽然看似结构简单，但这种病毒采用了不同寻常的基因组结构以及细胞质量控制途径的一些特殊用途，这些共同促成了令人惊讶的复杂多样的基因调控模式。在本综述中，我们将讨论MPyV如何利用这些不同途径来控制其生命周期。
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