Design, Synthesis and Antifungal Activity of Coumarin Ring-Opening Derivatives.

Based on our initial design, we synthesized two series of coumarin ring-opening derivatives by the reactions of hydrolysis and methylation. Results of antifungal screening in vitro showed that the target compounds exhibited potent activity against the six common pathogenic fungi. Compounds , , , , and were identified as the most active ones, and the EC values of these active compounds were further tested. Compared to the commonly used fungicide Azoxystrobin (0.0884 µM), compounds (0.0544 µM) and (0.0823 µM) displayed improved activity against .