韩国人膝关节骨关节炎、心血管危险因素与弗雷明汉风险评分之间的关联：一项横断面研究。
Association between Knee Osteoarthritis, Cardiovascular Risk Factors, and the Framingham Risk Score in South Koreans: A Cross-Sectional Study.
作者信息
Kim Ho Sun, Shin Joon-Shik, Lee Jinho, Lee Yoon Jae, Kim Me-Riong, Bae Young-Hyeon, Park Ki Byung, Lee Eun-Jung, Kim Joo-Hee, Ha In-Hyuk
机构信息
Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul, Republic of Korea.
Department of Korean Rehabilitation Medicine, College of Korean Medicine, Dae-Jeon University, Daejeon, Republic of Korea.
出版信息
PLoS One. 2016 Oct 20;11(10):e0165325. doi: 10.1371/journal.pone.0165325. eCollection 2016.
BACKGROUND
Osteoarthritis is a significant burden on personal health and for social cost, and its prevalence is rising. Recent research has revealed an association between osteoarthritis and cardiovascular disease, and this study uses the Framingham risk score (FRS), which is widely used as a composite index of cardiovascular risk factors, to investigate the association between osteoarthritis and various cardiovascular risk factors.
METHODS
A total 9,514 participants aged 50 years or older who received knee X-ray diagnosis of the 5th Korean National Health and Nutrition Examination Survey (total surveyees = 24,173) released by the Korean Centers for Disease Control and Prevention was included for analysis. Knee osteoarthritis patients were defined as participants with K-L grade ≥2 on knee X-ray regardless of knee pain. The association between major cardiovascular risk factors (blood pressure, diabetes, cholesterol, and smoking habits), FRS, and knee osteoarthritis was analyzed, adjusting for various covariates.
RESULTS
Prevalence of knee osteoarthritis in Koreans aged ≥50 years was 36.6%, and higher in women (men: 24.9%, women: 45.4%). Prevalence of knee osteoarthritis in participants with hypertension was significantly higher than those without hypertension (fully adjusted odds ratio (OR) 1.26; 95% confidence interval (CI) 1.08-1.48). Knee osteoarthritis prevalence was also higher in participants with impaired fasting glucose or diabetes than those without (age, sex adjusted OR 1.19; 95% CI 1.00-1.41). Also, OR values increased statistically significantly with FRS as a continuous variable (fully adjusted OR 1.007; 95% CI 1.00-1.01).
CONCLUSIONS
Prevalence of knee osteoarthritis was associated with hypertension and diabetes, which are major cardiovascular risk factors, and the FRS. Further studies on FRS pertaining to its relationship with osteoarthritis are warranted.
背景
骨关节炎给个人健康和社会成本带来了沉重负担，且其患病率正在上升。最近的研究揭示了骨关节炎与心血管疾病之间的关联，本研究使用广泛用作心血管危险因素综合指标的弗雷明汉风险评分（FRS），来调查骨关节炎与各种心血管危险因素之间的关联。
方法
纳入了韩国疾病控制与预防中心发布的第五次韩国国家健康与营养检查调查（总调查对象 = 24,173）中接受膝关节X线诊断的9514名50岁及以上参与者进行分析。膝关节骨关节炎患者定义为膝关节X线K-L分级≥2级的参与者，无论是否有膝关节疼痛。分析了主要心血管危险因素（血压、糖尿病、胆固醇和吸烟习惯）、FRS与膝关节骨关节炎之间的关联，并对各种协变量进行了校正。
结果
50岁及以上韩国人的膝关节骨关节炎患病率为36.6%，女性更高（男性：24.9%，女性：45.4%）。高血压参与者的膝关节骨关节炎患病率显著高于非高血压参与者（完全校正比值比（OR）1.26；95%置信区间（CI）1.08 - 1.48）。空腹血糖受损或患有糖尿病的参与者的膝关节骨关节炎患病率也高于非此类情况的参与者（年龄、性别校正OR 1.19；95% CI 1.00 - 1.41）。此外，作为连续变量的FRS的OR值在统计学上显著增加（完全校正OR 1.007；95% CI 1.00 - 1.01）。
结论
膝关节骨关节炎患病率与主要心血管危险因素高血压和糖尿病以及FRS相关。有必要对FRS与骨关节炎的关系进行进一步研究。
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