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韩国人心血管疾病史与慢性下腰痛之间的关联:一项横断面研究。

The association between the history of cardiovascular diseases and chronic low back pain in South Koreans: a cross-sectional study.

作者信息

Ha In-Hyuk, Lee Jinho, Kim Me-Riong, Kim Hyejin, Shin Joon-Shik

机构信息

Jaseng Medical Foundation, Jaseng Hospital of Korean Medicine, Seoul, Republic of Korea; Graduate School of Public Health & Institute of Health and Environment, Seoul National University, Gwanak-ro, Gwanak-gu, Seoul, Korea.

Jaseng Medical Foundation, Jaseng Hospital of Korean Medicine, Seoul, Republic of Korea; Department of Herbology, Graduate School of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.

出版信息

PLoS One. 2014 Apr 21;9(4):e93671. doi: 10.1371/journal.pone.0093671. eCollection 2014.

Abstract

BACKGROUND

Cardiovascular disease and related risk factors have been suggested as a mechanism leading to atherosclerosis of the lumbar vessels and consequent lumbar pain or sciatica. But there is continued controversy concerning its generalization. This study examined whether cardiovascular disease or its risk factors were associated with chronic low back pain (cLBP) in Koreans.

METHODS

Health surveys and examinations were conducted on a nationally representative sample (n = 23,632) of Koreans. A total of 13,841 eligible participants (aged 20 to 89 years) were examined to determine the association between cardiovascular disease, the Framingham risk score, major cardiovascular risk factors (blood pressure, diabetes, cholesterol, and smoking habits) and chronic LBP.

RESULTS

The total prevalence of cLBP was 16.6% (men: 10.8%, women: 21.1%) and that in patients with a history of cardiovascular diseases was 36.6% (men: 26.5%, women: 47.1%). The results showed that patients' medical history of cardiovascular disease was significantly associated with cLBP in both men and women when adjusted for covariates (men: OR 2.16; 95%CI 1.34∼3.49; women: OR 2.26; 95%CI 1.51∼3.38). No association was observed between cLBP and the Framingham risk score, medication for hyperlipemia, hypertension, diabetes, and major cardiovascular risk factors (systolic blood pressure, total cholesterol, high density lipoprotein cholesterol, triglycerides, glucose and smoking habits) in either men or women.

CONCLUSIONS

The prevalence of cLBP is correlated to a history of cardiovascular disease, but not to the major cardiovascular risk factors from the Framingham study. Further studies on whether these results were affected by psychological factors in patients with a history of cardiovascular diseases or whether new potential risk factors from the artery atherosclerosis hypothesis applying to Koreans exist are needed.

摘要

背景

心血管疾病及相关危险因素被认为是导致腰椎血管动脉粥样硬化以及随之而来的腰痛或坐骨神经痛的一种机制。但其普遍性仍存在持续争议。本研究调查了心血管疾病或其危险因素是否与韩国人的慢性下腰痛(cLBP)相关。

方法

对具有全国代表性的韩国样本(n = 23,632)进行健康调查和检查。共对13,841名符合条件的参与者(年龄在20至89岁之间)进行检查,以确定心血管疾病、弗雷明汉风险评分、主要心血管危险因素(血压、糖尿病、胆固醇和吸烟习惯)与慢性下腰痛之间的关联。

结果

cLBP的总患病率为16.6%(男性:10.8%,女性:21.1%),有心血管疾病病史的患者中cLBP患病率为36.6%(男性:26.5%,女性:47.1%)。结果显示,在调整协变量后,男性和女性患者的心血管疾病病史均与cLBP显著相关(男性:OR 2.16;95%CI 1.34∼3.49;女性:OR 2.26;95%CI 1.51∼3.38)。在男性或女性中,均未观察到cLBP与弗雷明汉风险评分、高脂血症用药、高血压、糖尿病及主要心血管危险因素(收缩压、总胆固醇、高密度脂蛋白胆固醇、甘油三酯、血糖和吸烟习惯)之间存在关联。

结论

cLBP的患病率与心血管疾病病史相关,但与弗雷明汉研究中的主要心血管危险因素无关。需要进一步研究这些结果是否受到有心血管疾病病史患者心理因素的影响,或者是否存在适用于韩国人的动脉粥样硬化假说中的新潜在危险因素。

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