Han C M
Department of Burns, the Second Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou 310009, China.
Zhonghua Shao Shang Za Zhi. 2016 Oct 20;32(10):580-581. doi: 10.3760/cma.j.issn.1009-2587.2016.10.002.
The wound healing includes non-healing and overhealing of the wounds. The results of wound healing are well known by people such as non-healing of the diabetic ulcer or hypertrophic scar after deep burn. In this issue, three papers involve in wound healing, one about autologous adipose-derived mesenchymal stem cells injected into wound or scar of rabbit ear, one about severe hypoxia and hypoalbuminemia inducing human hypertrophic scar derived fibroblast apoptosis in vitro, and another about the dysfunction of protein kinase B/mammalian target of rapamycin signaling pathway contributing to the pathophysiological characteristics of diabetic skin and non-healing wound. The basic problem of hypertrophic scar study is lacking an ideal animal model. Although rabbit ear model or red Duroc pig model has been used widely for study on hypertrophic scar, they can not fully represent human dermal fibrosis after deep trauma on the skin. I recommend recently published in to the readers. The author emphasizes that the wound healing study is still in the situation like the game of " blind men and an elephant" .
伤口愈合包括伤口不愈合和过度愈合。伤口愈合的结果为人们所熟知，比如糖尿病溃疡不愈合或深度烧伤后形成增生性瘢痕。在本期中，有三篇论文涉及伤口愈合，一篇是关于将自体脂肪间充质干细胞注射到兔耳伤口或瘢痕中，一篇是关于严重缺氧和低白蛋白血症在体外诱导人增生性瘢痕来源的成纤维细胞凋亡，另一篇是关于蛋白激酶B/雷帕霉素靶蛋白信号通路功能障碍导致糖尿病皮肤和不愈合伤口的病理生理特征。增生性瘢痕研究的基本问题是缺乏理想的动物模型。尽管兔耳模型或红色杜洛克猪模型已被广泛用于增生性瘢痕研究，但它们不能完全代表人类皮肤深度创伤后的真皮纤维化。我向读者推荐最近发表在 上的文章。作者强调，伤口愈合研究仍处于“盲人摸象”的状态。
