Zhang J W, Zeng Q, Zhao L, Zhang M, Zhang L, Gu Q
Graduate School of Tianjin Medical University, Tianjin 300070, China.
Tianjin Center for Disease Control and Prevention, Tianjin 300011, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2016 Oct 10;37(10):1413-1416. doi: 10.3760/cma.j.issn.0254-6450.2016.10.019.
To investigate the association between parental environmental risk factors exposure and the risk for childhood acute lymphoblastic leukemia (ALL). A total of 179 ALL children cases were selected in Tianjin Blood Disease Hospital and 136 healthy children matched by age, gender and living place were selected in 2015 for a case control study. The data were analyzed with univariate and multivariate non conditional logistic regression models. The results of multivariate logistic regression analysis indicated that sex, history of abortion, exposure in a smoking environment during pregnancy, catching a cold, taking antipyretic analgesics, maternal exposure to air purifying agent, father' s occupational exposure to petroleum products and home decoration during pregnancy were associated with the risk of childhood ALL (<0.05) and the results of multivariate logistic regression analysis indicated that sex, history of abortion, catching a cold, father's occupational exposure to petroleum products and home decoration during pregnancy were associated with the risk of childhood ALL (<0.05). The five factors including sex, history of abortion, catching a cold, father' s occupational exposure to petroleum products and home decoration during pregnancy were risk factors for childhood ALL.
为研究父母暴露于环境危险因素与儿童急性淋巴细胞白血病（ALL）风险之间的关联。2015年，在天津血液病医院选取了179例ALL患儿病例，并选取了136名年龄、性别和居住地匹配的健康儿童进行病例对照研究。采用单因素和多因素非条件logistic回归模型对数据进行分析。多因素logistic回归分析结果显示，性别、流产史、孕期暴露于吸烟环境、感冒、服用解热镇痛药、母亲接触空气净化剂、父亲职业性接触石油产品以及孕期家庭装修与儿童ALL风险相关（<0.05），且多因素logistic回归分析结果显示，性别、流产史、感冒、父亲职业性接触石油产品以及孕期家庭装修与儿童ALL风险相关（<0.05）。性别、流产史、感冒、父亲职业性接触石油产品以及孕期家庭装修这五个因素是儿童ALL的危险因素。
