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站在胡布雷希特的肩膀上:从胚胎到干细胞。

On the shoulders of Hubrecht: From embryos to stem cells.

作者信息

Rabouille Catherine, Deschamps Jacqueline

机构信息

Hubrecht Institute - Koninklijke Nederlandse Akademie van Wetenschappen (KNAW) and University Medical Center Utrecht, Upsalalaan 8, 3584 CT Utrecht, The Netherlands.

出版信息

Dev Biol. 2017 Aug 15;428(2):264-272. doi: 10.1016/j.ydbio.2016.10.005. Epub 2016 Oct 17.

Abstract

One hundred years of the Hubrecht Institute were celebrated in May 2016 with the organization of a one-day symposium "From embryos to stem cells" on the Uithof Campus, Utrecht, the Netherlands. Nine distinguished speakers were invited. They all represent a research branch originating from the passion of Institute founder, Ambrosius Hubrecht, for embryology:, regulation of gene expression, genome structure and function, embryonic and adult stem cells, nuclear reprogramming, and understanding cancer and other diseases using model organisms. The centennial symposium not only retraced the history of the Institute and of modern developmental biology, but was also a tribute to basic research. From there, avenues to therapeutics are being developed and implemented. The symposium was organized, introduced and chaired by Jeroen den Hertog and Alexander van Oudenaarden, the present Directors of the Institute, who also stand on Hubrecht's shoulders.

摘要

2016年5月,位于荷兰乌得勒支市惠更斯校园的胡布勒支研究所举办了一场为期一天的主题为“从胚胎到干细胞”的研讨会,以此庆祝该研究所成立一百周年。会上邀请了九位杰出的演讲者。他们都代表了一个研究分支,这些分支源于研究所创始人安布罗修斯·胡布勒支对胚胎学的热爱:基因表达调控、基因组结构与功能、胚胎干细胞和成体干细胞、核重编程,以及使用模式生物来理解癌症和其他疾病。这次百年研讨会不仅回顾了该研究所及现代发育生物学的历史,也是对基础研究的一次致敬。由此,通往治疗方法的途径正在被开发和应用。本次研讨会由该研究所现任所长杰伦·登·赫托赫和亚历山大·范·奥德纳arden组织、介绍并主持,他们也是站在胡布勒支的肩膀上前行。 (注:原文中“Alexander van Oudenaarden”的“arden”疑似拼写错误,推测可能是“Alexander van Oudenaard”,这里按原文翻译。)

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