Pitts W C, Berry G J
Department of Pathology, Stanford University Medical Center, CA 94305.
Diagn Cytopathol. 1989;5(2):200-2. doi: 10.1002/dc.2840050216.
A case of metastatic follicular carcinoma to the iliac bone in a 78-yr-old woman is presented. Fine-needle aspiration biopsy (FNAB) smears showed numerous, cohesive tumor cell groups with moderately abundant cytoplasm and distinctive, peripherally situated pink-staining vacuoles on May-Grünwald-Giemsa stain. The presence of marginal vacuoles strongly suggested the possibility of metastatic thyroid carcinoma. Immunohistochemical studies performed on a concomitant needle core biopsy showed immunoreactivity for thyroglobulin, supporting a thyroid derivation for this metastasis. To our knowledge, this is the first reported case in which marginal vacuoles ("flame cells") have been identified in a malignant thyroid condition.
本文报告了一例78岁女性发生髂骨转移性滤泡癌的病例。细针穿刺活检（FNAB）涂片显示，May-Grünwald-Giemsa染色下可见大量聚集的肿瘤细胞团，细胞质中度丰富，有独特的位于周边的粉红色染色空泡。边缘空泡的存在强烈提示转移性甲状腺癌的可能性。对同时进行的针芯活检组织进行免疫组化研究显示甲状腺球蛋白呈免疫反应性，支持该转移灶来源于甲状腺。据我们所知，这是首例在恶性甲状腺疾病中发现边缘空泡（“火焰细胞”）的报道病例。
