Rubini Alessandro, Catena Vincenzo, Del Monte Daniele, Bosco Gerardo
a Department of Biological Sciences, Section of Physiology , University of Padova , Padova , Italy.
b Department of Emergency and Intensive Care , ULSS 2 , Feltre , Italy.
J Enzyme Inhib Med Chem. 2017 Dec;32(1):1-4. doi: 10.1080/14756366.2016.1225045. Epub 2016 Oct 21.
Calcium channel blockers may theoretically exhibit relaxing effects not only on vascular smooth muscle but also on airway smooth muscle.
To investigate possible effects of nifedipine on respiratory mechanics in the rat.
Respiratory system mechanical parameters were measured by the end-inflation occlusion method in the rat in vivo before and after the intraperitoneal administration of nifedipine.
We found that nifedipine affects respiratory mechanics, inducing a reduction of airway resistance and of respiratory system elastance, probably because of a relaxing action on airway and parenchimal smooth muscle cells.
Should these results be further confirmed by human investigations, a possible role of nifedipine in pharmacological respiratory system's diseases treatment may be suggested.
理论上，钙通道阻滞剂不仅可能对血管平滑肌有舒张作用，对气道平滑肌也有舒张作用。
研究硝苯地平对大鼠呼吸力学的可能影响。
采用终末充气阻断法，在大鼠体内腹腔注射硝苯地平前后测量呼吸系统力学参数。
我们发现硝苯地平影响呼吸力学，导致气道阻力和呼吸系统弹性降低，这可能是由于其对气道和实质平滑肌细胞的舒张作用。
如果这些结果能得到人体研究的进一步证实，可能提示硝苯地平在药理治疗呼吸系统疾病方面具有潜在作用。
