a Department of Biomedical Sciences , University of Padova , Padova , Italy and.
b Centre of Mechanics of Biological Materials, University of Padova , Padova , Italy.
J Enzyme Inhib Med Chem. 2016 Dec;31(6):890-3. doi: 10.3109/14756366.2016.1158174. Epub 2016 Mar 22.
Endocrinological factors have been recently described to affect respiratory mechanics.
To review recent literature data, most of all obtained by the end-inflation occlusion method, describing the effects of molecules of endocrinological interest such as endothelin, erythropoietin and renin-angiotensin, on respiratory mechanics parameters.
The papers considered in this review were found by inserting in Pubmed/Medline the following indexing terms: hormones, endothelin, erythropoietin, angiotensin and respiratory mechanics.
It was found that the above cited molecules, beside their well known physiological main effects, exhibit influences on respiratory mechanics, most of all on the airflow resistance, which was described to be increased by endothelin and angiotensin, and decreased by erythropoietin.
A number of molecules of biological interest exhibit unexpected influences on respiratory mechanics. The clinical effects depend on the consequences of modified inspiratory pressure values the respiratory muscles have to perform for a given breathing pattern.
内分泌因素最近被描述为影响呼吸力学。
综述最近的文献数据，这些数据主要是通过终末吸气阻断法获得的，描述了内分泌相关分子（如内皮素、促红细胞生成素和肾素-血管紧张素）对呼吸力学参数的影响。
在 Pubmed/Medline 中插入以下索引词来查找本综述中考虑的论文：激素、内皮素、促红细胞生成素、血管紧张素和呼吸力学。
结果发现，除了已知的主要生理作用外，上述提到的分子对呼吸力学也有影响，主要是对气流阻力的影响，内皮素和血管紧张素可增加阻力，促红细胞生成素可降低阻力。
许多具有生物学意义的分子对呼吸力学有意外的影响。临床效果取决于呼吸肌在给定呼吸模式下为实现给定吸气压力值而必须执行的后果。
