从亚洲中部紫菀地上部分分离抗氧化和α-葡萄糖苷酶抑制黄酮类化合物。
Separation of antioxidant and α-glucosidase inhibitory flavonoids from the aerial parts of Asterothamnus centrali-asiaticus.
作者信息
Wang Yan-Ming, Zhao Jian-Qiang, Yang Jun-Li, Tao Yan-Duo, Mei Li-Juan, Shi Yan-Ping
机构信息
a Key Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics , Chinese Academy of Sciences , Lanzhou , P.R. China.
b Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology , Chinese Academy of Sciences , Xining , P.R. China.
出版信息
Nat Prod Res. 2017 Jun;31(12):1365-1369. doi: 10.1080/14786419.2016.1247083. Epub 2016 Oct 21.
A new flavonoid, along with 16 known ones, was separated from the aerial parts of Asterothamnus centrali-asiaticus. Their structures were elucidated by extensive spectroscopic methods, including 1D and 2D NMR techniques and HRESIMS. To confirm the structure of the new compound, computational prediction of its C chemical shifts was performed. All of the 17 flavonoids were reported from A. centrali-asiaticus for the first time. In addition, all flavonoids were evaluated for their antioxidant and α-glucosidase inhibitory activities. The results showed that 10 of them exhibited antioxidant activity. Meanwhile, four flavonoids displayed α-glucosidase inhibitory effect with IC values ranging from 38.9 to 299.7 μM.
从中亚紫菀木的地上部分分离出一种新的黄酮类化合物以及16种已知的黄酮类化合物。通过广泛的光谱方法，包括一维和二维核磁共振技术以及高分辨电喷雾电离质谱对它们的结构进行了阐明。为了确定新化合物的结构，对其碳化学位移进行了计算预测。这17种黄酮类化合物均首次从中亚紫菀木中报道。此外，对所有黄酮类化合物的抗氧化活性和α-葡萄糖苷酶抑制活性进行了评估。结果表明，其中10种具有抗氧化活性。同时，4种黄酮类化合物表现出α-葡萄糖苷酶抑制作用，IC值范围为38.9至299.7 μM。
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