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不同突变品种的代谢物谱分析及二肽基肽酶IV抑制活性

Metabolite Profiling and Dipeptidyl Peptidase IV Inhibitory Activity of Cultivars in Different Mutations.

作者信息

Kim Bo-Ram, Paudel Sunil Babu, Han Ah-Reum, Park Jisu, Kil Yun-Seo, Choi Hyukjae, Jeon Yeo Gyeong, Park Kong Young, Kang Si-Yong, Jin Chang Hyun, Kim Jin-Baek, Nam Joo-Won

机构信息

Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup-si 56212, Jeollabuk-do, Korea.

Natural Product Research Division, Honam National Institute of Biological Resources, Mokpo-si 58762, Jeollanam-do, Korea.

出版信息

Plants (Basel). 2021 Aug 12;10(8):1661. doi: 10.3390/plants10081661.

DOI:10.3390/plants10081661
PMID:34451706
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8401970/
Abstract

species have been developed to produce cultivars of various floral colors and sizes and are also used in traditional medicine. To identify and evaluate mutant cultivars of . and . , their phytochemical profiles were systematically characterized using ultra-performance liquid chromatography time-of-flight mass spectrometry, and their anti-diabetic effects were evaluated using the dipeptidyl peptidase (DPP)-IV inhibitor screening assay. Forty compounds were tentatively identified. This study is the first to provide comprehensive chemical information on the anti-diabetic effect of . and . . All 32 methanol extracts of cultivars inhibited DPP-IV activity in a concentration-dependent manner (IC values: 34.01-158.83 μg/mL). Thirteen compounds presented as potential markers for distinction among the 32 cultivars via principal component analysis and orthogonal partial least squares discriminant analysis. Therefore, these bio-chemometric models can be useful in distinguishing cultivars as potential dietary supplements for functional plants.

摘要

已培育出多种品种以生产各种花色和大小的栽培品种，并且它们也被用于传统医学。为了鉴定和评估……和……的突变栽培品种，使用超高效液相色谱飞行时间质谱对它们的植物化学特征进行了系统表征，并使用二肽基肽酶（DPP）-IV抑制剂筛选试验评估了它们的抗糖尿病作用。初步鉴定出40种化合物。本研究首次提供了关于……和……抗糖尿病作用的全面化学信息。所有32种……栽培品种的甲醇提取物均以浓度依赖性方式抑制DPP-IV活性（IC值：34.01-158.83μg/mL）。通过主成分分析和正交偏最小二乘判别分析，有13种化合物作为区分32种……栽培品种的潜在标志物。因此，这些生物计量模型可用于区分作为功能性植物潜在膳食补充剂的栽培品种。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a905/8401970/6c7f6f4f16f7/plants-10-01661-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a905/8401970/d2bd962d0132/plants-10-01661-g001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a905/8401970/5662381946b8/plants-10-01661-g002a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a905/8401970/6c7f6f4f16f7/plants-10-01661-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a905/8401970/d2bd962d0132/plants-10-01661-g001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a905/8401970/5662381946b8/plants-10-01661-g002a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a905/8401970/6c7f6f4f16f7/plants-10-01661-g003.jpg

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