Kellokumpu-Lehtinen P
Department of Radiotherapy, University of Turku, Finland.
Eur Urol. 1989;16(5):386-90. doi: 10.1159/000471623.
We have studied embryonic and fetal differentiation of the human prostate in relation to androgen-producing Leydig cell differentiation. We have studied the differentiation of human prostatic glands and the synthesis of acid phosphatase in vivo and in vitro. These studies have shown that the mesenchyme at the level of the openings of the para- and mesonephric ducts to the urethra was the local initiator of prostatic differentiation. All prostatic acini developed by epithelial outgrowths from the urethral epithelium. None of them grew from para- or mesonephric ducts. However, the epithelium on the colliculus seminalis differed from the rest of the urethral epithelium morphologically and in acid phosphatase content. Androgens accelerated differentiation in vitro and acid phosphatase activity was shown to be present in prostatic urethral epithelium and prostatic acini both in vivo and in vitro. According to these studies embryonic differentiation gives no direct answer to the localisation of adult neoplastic changes in different parts of the prostate, although in the posterior part there might be a mixture of cells from ductal and urethral epithelium. Secretion of acid phosphatase seems to be a constitutional phenomenon of this part of epithelium and is partly regulated by androgens. Epitheliomesenchymal interaction is important in differentiation and the role of this interaction in adult diseases might be valuable to be studied.
我们研究了人类前列腺的胚胎和胎儿分化与产生雄激素的睾丸间质细胞分化之间的关系。我们研究了人类前列腺腺泡的分化以及体内和体外酸性磷酸酶的合成。这些研究表明，副中肾管和中肾管开口至尿道水平的间充质是前列腺分化的局部启动者。所有前列腺腺泡均由尿道上皮的上皮增生发育而来。它们均非起源于副中肾管或中肾管。然而，精阜上的上皮在形态和酸性磷酸酶含量上与尿道其余上皮不同。雄激素在体外加速分化，并且在体内和体外均显示酸性磷酸酶活性存在于前列腺尿道上皮和前列腺腺泡中。根据这些研究，胚胎分化并未直接回答前列腺不同部位成人肿瘤性病变的定位问题，尽管在前列腺后部可能存在导管上皮和尿道上皮细胞的混合。酸性磷酸酶的分泌似乎是该部分上皮的一种固有现象，并且部分受雄激素调节。上皮-间充质相互作用在分化中很重要，这种相互作用在成人疾病中的作用可能值得研究。
