Kellokumpu-Lehtinen P
Biol Neonate. 1985;48(3):157-67. doi: 10.1159/000242167.
The histological differentiation of the human fetal prostatic urethra and the corresponding part of human fetal female urethra was studied during the 10th through 14th weeks of ovulation age. The development of all the prostatic glands started as epithelial outgrowths from the urethral wall of the urogenital sinus during the time covered in this study. These outgrowths grew rapidly in number and size, especially the posterior ones, and no outgrowths were seen from the paramesonephric and mesonephric ducts. However, the more columnar epithelial cells on the colliculus seminalis, from which the middle and posterior lobes developed, may be of different embryonic origin, e.g. mesonephric, paramesonephric and urethral, or may react differently to hormonal factors. The possible differences in the origin and in the morphological differentiation of the epithelial cells may give clues to the differences in localization of neoplastic changes in adult prostate. The gland formation was preceded by mesenchymal changes which progressed during acinic morphogenesis. Mesenchymal cells differentiated into fibroblasts forming a lamina propria the primitive acini. The mesenchymal differentiation in the corresponding part of the female urethra was not equally prominent. However, the increase in urethral epithelial cells density and cell size was more prominent in the females. These morphological differences might be regulated by sex steroids and further strengthen the current view of the role of the mesenchyme in the prostatic morphogenesis.
在排卵年龄的第10至14周期间，对人胎儿前列腺尿道及人胎儿女性尿道相应部位进行了组织学分化研究。在本研究涵盖的时间段内，所有前列腺腺体的发育均始于泌尿生殖窦尿道壁的上皮增生。这些增生在数量和大小上迅速增加，尤其是后部的增生，而中肾管和副中肾管未见增生。然而，精阜上发育出中叶和后叶的柱状上皮细胞可能有不同的胚胎起源，如中肾、副中肾和尿道起源，或者对激素因素有不同反应。上皮细胞起源和形态分化的可能差异可能为成人前列腺肿瘤性改变的定位差异提供线索。腺泡形成之前有间充质变化，这些变化在腺泡形态发生过程中不断进展。间充质细胞分化为成纤维细胞，形成固有层和原始腺泡。女性尿道相应部位的间充质分化不那么明显。然而，女性尿道上皮细胞密度和细胞大小的增加更为显著。这些形态学差异可能受性类固醇调节，并进一步强化了目前关于间充质在前列腺形态发生中作用的观点。
